基于"炎癌转化"理论探讨NETs与肺癌转移的关系OA

Lung cancer,as a public health issue affecting modern society and individual health,is closely associ-ated with the presence of inflammation in its development and progression.According to traditional Chinese medicine theory,"deficiency of the body's defensive energy and accumulation of toxins"is the key pathogenic mechanism un-derlying the occurrence and development of lung cancer.The continuous accumulation of toxins ultimately promotes the"inflammation-to-cancer"transformation and is closely related to lung cancer metastasis.Multiple studies have shown that neutrophil extracellular traps(NETs)interact with cancer cells,with NETs enhancing inflammatory re-sponses and accelerating the inflammation-to-cancer transformation.Based on this,we propose the"inflammation-to-cancer transformation-abnormal NET release-lung cancer metastasis"etiological and pathomechanical perspective,of-fering new insights for clinical treatment.