基于"诸痿发于肺热"理论探讨TGF-β1/Smad信号通路在间质性肺病并发骨质疏松症中的作用机制OA

Interstitial lung disease(ILD)is a group of diseases with diffuse alveolitis and interstitial fibrosis as the main pathological manifestations.Osteoporosis(OP)is one of the common complications of ILD,which is mani-fested by decreased bone mass and bone strength.In Chinese medicine,ILD and OP belong to the categories of"lung impotence"and"bone impotence",respectively,and the interaction and coexistence of ILD and OP pose a great chal-lenge to clinical diagnosis and treatment,which seriously affects the quality of patient's survival.The TGF-β1/Smad signaling pathway shows positive and negative feedback regulation in interstitial fibrosis and bone metabolism.Ab-normal TGF-β1/Smad signaling is closely related to lung fever,which disturbs the homeostasis of the internal envi-ronment and plays an important role in the development of ILD combined with OP.Based on the theory of"all impo-tence originates from lung heat"in Chinese medicine,this article discusses the mechanism of TGF-β1/Smad signaling pathway in ILD with osteoporosis,with the aim of providing a new theoretical basis for clinical diagnosis and treat-ment and ideas for targeted therapy.