沙眼衣原体逃避宿主固有免疫的研究进展OA

Chlamydia trachomatis(Ct)is the pathogen responsible for the most common bac-terial sexually transmitted disease.Its unique intracellular survival mode and complex immune evasion mechanisms enable it to establish long-term infections within the host,triggering severe chronic pathological reactions.This review provides insights into Ct's biological characteristics and various innate immune evasion strategies.The key roles of the cGAS-STING signaling pathway and crucial innate immune cells in host anti-infection responses are emphasized.The molecular mecha-nisms by which Ct achieves immune evasion,such as interfering with the γ-interferon response,manipulating host cell death,and inhibiting antigen presentation,are also elaborated.