经典型卡波西肉瘤3例OA

Three cases of classic Kaposi's sarcoma are reported and the relevant literature is reviewed.Case 1 was a 69-year-old man.Purplish-red papules and nodules on both feet lasted for 3 years and worsened for half a year.Dermatological examination revealed multiple dark purplish-red papules and nodules of varying sizes on both dorsal feet,soles,dorsal hands,and palms.Some were hemispherical in shape,while others fused into plaques.Black scabs were noticed on some surfaces,accompanied by a moderate texture and mild tenderness.Both lower limbs exhibi-ted non-pitting edema.Case 2 was a 70-year-old man with purplish-red papules and nodules on both lower legs and feet for 4 years.Dermatological examination showed dark purplish-red papules and nodules on both lower legs,dorsal feet,and the right ankle.Some of these were hemispher-ical,with a rough and thick surface,without tenderness.Both lower limbs had non-pitting edema.Case 3 involved a 73-year-old man who experienced purplish-red papules and nodules on the left lower leg for 2 years,with worsening over the past month.Dermatological examination revealed multiple dark purplish-red nodules measuring 0.5-1 cm in diameter on the left lower leg,appea-ring hemispherical with slight tenderness.The HIV antibody test for all three patients was nega-tive.Histopathological examination of all three patients showed characteristic features of spindle cells and vascular proliferation,with positive immunohistochemical staining for CD34,CD31,HHV8,and Fil-1.Kaposi's sarcoma was diagnosed based on clinical manifestations,skin his-topathological examination,and immunohistochemistry.Follow up:Patient 1 discontinued treat-ment due to personal financial reasons.Patients 2 and 3 received regular radiation therapy at the Cancer Radiotherapy Department of our hospital.After six months of treatment,a telephone fol-low-up was conducted.Patient 2 reported that most of the skin lesions had subsided,and treat-ment had been discontinued for one month,with occasional recurrence.After 7 months of treat-ment,a follow-up call was made to patient 3,who reported partial subsidence with occasional re-currence.The patient is currently still undergoing treatment.