头皮乳头状汗管囊腺癌1例及文献复习OA

This article reports a case of SCACP in a 27-year-old female with a congenital scalp mass for 27 years,which exhibited surface ulceration and crusting in the recent 2 years.Pathologi-cal examination revealed infiltrative growth of the tumor with basaloid and squamous differentia-tion.Immunohistochemistry showed BerEP4(+),EMA(+),P40(+),GCDFP-15(+),CK7(+),and Ki-67(10％+).This article also systematically reviews the epidemiological characteristics,clinicopathological features,immunohistochemical diagnostic criteria and differen-tial diagnosis of SCACP.In addition,it discusses the principles of staging,surgical treatment strategies(including indications for lymph node dissection),the clinical significance of radiothera-py and chemotherapy,and the application value of NGS testing in targeted therapy selection.Fur-thermore,it analyzes the key factors affecting prognosis and strategies for improving survival rate,aiming to provide reference for clinical diagnosis and treatment.