樱花组合物的应用研究:敏感头皮护理与防脱发功效OA

Objective To verify the effects of a cost-effective,low-concentration,and sensi-tive scalp-friendly anti-hair loss cherry blossom composition(PSC),aimed at overcoming the limi-tations of existing strategies which focus solely on stopping hair loss while neglecting the scalp care,and the reliance on a single cherry blossom extract at high concentration.Methods The composition of PSC was prepared,and the DPPH antioxidant assay was used to evaluate its free radical scavenging ability.The inhibition of PSC on TNF-α and IL-1 β was assessed to evaluate its soothing effect.The effects of PSC on oil control and prevention of hair loss were measured by as-sessing the inhibition of 5α-reductase activity in both the liver and epididymis.A total of 30 sub-jects with sensitive scalps were enrolled in this study.A 12-week clinical trial was conducted to e-valuate hair loss and overall hair density,and a questionnaire was used to assess the scalp condi-tion,hair density,and prevention of hair loss.Results The DPPH radical scavenging rate of PSC was 8.03％.PSC inhibited TNF-α and IL-1β by 30.70％and 44.40％,respectively,while in-hibiting 5 α-reductase by 42.59％(epididymis-derived)and 37.50％(liver-derived).Treatment of the scalp with a scalp essence for 12 weeks decreased hair loss by 14.79％(P＜0.001),while increasing hair density by as much as 33.33％,with an average increase of 5.32％(P＜0.05).Questionnaires showed that over 80％ of participants reported decreased scalp sebum secretion,re-duced sensitivity or discomfort,and noticeable reduction in hair loss.Conclusion PSC with a low concentration of PS can achieve the dual efficacy in scalp care and anti-hair loss,providing a high-ly effective and cost-efficient solution for individuals with sensitive scalps.