肉芽肿性玫瑰痤疮临床及病理特征分析OA

Objective To explore the clinical manifestations,histopathological features,diag-nosis,and therapeutic characteristics of granulomatous rosacea(GR),thereby enhancing the clin-ical physicians' understanding of this condition.Methods This study conducted a retrospective a-nalysis of clinical and pathological features of 14 cases of GR at Guangzhou Dermatology Hospital from June 2019 to May 2021.Results Among 14 patients,11 were female,and 3 were male.The most frequently involved area was the cheek,and none of the patients showed extrafacial le-sions.Histologically,the mixed type was the most common(64.29％,9/14),followed by the perifollicular type(28.57％,4/14)and nodular type(7.14％,1/14).None of the biopsy spec-imens showed diffuse granulomatous infiltration.Among the confirmed cases,71.43％(10/14)of patients had previously received oral treatments such as antihistamines,hydroxychloroquine,or tetracycline antibiotics,but the therapeutic effects were unsatisfactory.After diagnosis,the pa-tients adopted the treatment plan of oral isotretinoin combined with low-dose prednisone,resulting in gradual subsidence of the skin lesions.Conclusions GR is more common in middle-aged women.The typical skin lesions are symmetrical papules and erythema on both cheeks with mild subjective symptoms.The histopathological feature is primarily a mixed type of non-caseous epi-thelioid cell granuloma.The clinical misdiagnosis rate of GR is high,and a clear diagnosis should be made by combining the characteristic clinical manifestations with histopathological examination.Oral isotretinoin combined with low-dose glucocorticoid therapy has proven effective.