成纤维细胞乙醇脱氢酶1B基因在腹主动脉瘤中的潜在作用OA
Identification and validation of a carbohydrate metabolism related key gene associated with fibro-blast in abdominal aortic aneurysm
目的 探讨乙醇脱氢酶1B基因(ADH1B)在腹主动脉瘤中的潜在作用.方法 采用生物信息学技术,综合分析人类腹主动脉瘤和正常腹主动脉组织样本的转录组和单细胞数据.通过参考碳水化合物代谢数据集,采用逻辑回归筛选出代谢相关标志基因ADH1B.结果 成纤维细胞中的ADH1B基因可能通过调节平滑肌细胞表型转换,参与抑制腹主动脉瘤的发生发展.结论 ADH1B基因对腹主动脉瘤具有保护作用.
Objective To explore the potential role of the(alcohol dehydrogenase 1B,ADH1B)ADH1B gene in abdominal aortic aneurysms(AAA).Methods Utilizing bioinformatics techniques,we conducted a comprehensive analysis of transcriptome and single-cell data from human AAA and normal abdominal aorta tissue samples.The metabolism-related marker gene ADH1B was identified using logistic regression analysis of carbohydrate metabolism datasets.Results The fibroblast ADH1B gene may be involved in protecting against the development of AAA by modulating smooth muscle cell phenotypic changes.Conclusion The ADH1B gene appears to have a protective role in abdominal aortic aneurysms.
李根;赵子牛;石展岳
阜外华中心血管病医院成人心脏外科,郑州 450000阜外华中心血管病医院成人心脏外科,郑州 450000中山大学孙逸仙纪念医院心血管外科,广州 510030
医药卫生
ADH1B腹主动脉瘤生物信息学
ADH1Babdominal aortic aneurysmsbioinformatics
《岭南现代临床外科》 2026 (1)
33-41,9
国家自然科学基金(82271806)阜外华中心血管病医院科研培育项目(FWKY250038FWKY240009)
评论