急性脑梗死患者血清ANXA2、GSH-Px水平与梗死程度的关系及对介入术后预后不良的预测价值OA

Objective To investigate the relationship of serum annexin A2(ANXA2)and glutathione per-oxidase(GSH-Px)levels with infarction severity and their predictive value for poor prognosis after interven-tional therapy in patients with acute cerebral infarction(ACI).Methods A total of 120 patients with ACI who underwent interventional therapy at the hospital from August 2022 to August 2024(the ACI group)and 120 healthy controls(the control group)were enrolled as research subjects.The ACI patients were categorized into severe,moderate and mild infarction groups based on infarct size,and were also divided into poor and good prognosis groups according to the modified Rankin Scale(mRS)score at 3 months post-surgery.Serum ANXA2 level of all research subjects was measured by enzyme-linked immunosorbent assay,and GSH-Px lev-el of all research subjects was determined by colorimetry.Spearman correlation analysis was performed to e-valuate the relationship of ANXA2 and GSH-Px levels with infarction severity in ACI patients.Multivariate Logistic regression analysis was applied to identify factors affecting the poor prognosis of ACI patients after interventional therapy.Receiver operating characteristic(ROC)curve was used to assess the predictive value of serum ANXA2 and GSH-Px levels for poor prognosis of ACI patients after interventional therapy.Results Serum ANXA2 level in the ACI group was found to be significantly higher than that in the control group(P<0.05),whereas GSH-Px level was significantly lower(P<0.05).Serum ANXA2 level in the se-vere infarction group was higher than that in the moderate and mild infarction groups(P<0.05),and serum ANXA2 level in the moderate group was higher than that in the mild group(P<0.05).Conversely,GSH-Px level in the severe infarction group was lower than that in the moderate and mild infarction groups(P<0.05),with level in the moderate group being lower than that in the mild group(P<0.05).Serum ANXA2 level was positively correlated with infarction severity(P<0.05),and GSH-Px level was negatively correlated with infarction severity(P<0.05).Infarct size,National Institutes of Health Stroke Scale score and ANXA2 level in the poor prognosis group were higher than those in the good prognosis group(P<0.05),while GSH-Px level was lower(P<0.05).Larger infarct size and elevated ANXA2 level were identified as independent risk factors for poor prognosis(P<0.05),while elevated GSH-Px level was determined to be a protective fac-tor(P<0.05).The area under the curve(AUC)for the combination of ANXA2 and GSH-Px in predicting poor prognosis was calculated as 0.943,which was significantly greater than the AUC for ANXA2 alone(Z=2.176,P<0.05)and GSH-Px alone(Z=2.031,P<0.05).Conclusion Serum ANXA2 level is elevated and GSH-Px level is decreased in patients with ACI.Both biomarkers show significant correlations with the severi-ty of cerebral infarction.Their combined detection demonstrates high predictive value for poor prognosis after interventional therapy.