金合欢素对酒精诱导小鼠肝损伤的保护作用OA

Aims to investigate the effects of acacia saponin on alcohol-induced liver tissue damage in mice.After inducing liver injury through alcohol gavage,mice were euthanized,body mass and liver mass were measured,liver morphological changes were observed via HE staining,alanine aminotransferase activity in serum was detected using a kit,and mRNA expression levels of inflammatory factor-related genes IL-6,IL-10,TNFα and antioxidant-related genes SOD,Nrf2,HO-1,NQO1 were assessed.Results showed that compared with the control group(CK)mice in the model group(Model)exhibited significantly elevated serum ALT activity,upregulation of mRNA expression levels for pro-inflammatory genes,and downregulation of mRNA expression levels for antioxidant-related genes.Compared with the Model group,both the low-dose acacia-lactone intervention group(Model+LACA)and the high-dose intervention group(Model+HACA)exhibited significantly reduced ALT activity,decreased mRNA expression levels of pro-inflammatory genes,and increased mRNA expression levels of antioxidant enzyme genes.The results indicate that acacia reticulata extract alleviates alcohol-induced liver injury in mice.These findings provide experimental evidence supporting the application of acacia reticulata extract in the prevention and treatment of alcoholic liver disease.