血清GGT、Gal-3对慢性心力衰竭并发心律失常患者预后不良的预测价值OA
Predictive value of serum γ-glutamyltransferase and galectin-3 for poor prognosis in patients with chronic heart failure complicated by arrhythmia
目的 探讨血清γ-谷氨酰转移酶(GGT)、半乳糖凝集素-3(Gal-3)对慢性心力衰竭(CHF)并发心律失常患者预后不良的预测价值.方法 选取2022年6月至2024年1月滁州市第一人民医院收治的121例CHF并发心律失常患者作为研究组,根据患者预后情况分为预后不良组和预后良好组,另选取同期121例单纯CHF患者作为CHF组,同期121例体检健康者作为对照组.比较各组血清GGT、Gal-3水平及预后不良组、预后良好组心功能指标[脑钠肽(BNP)、左心室射血分数(LVEF)].采用多因素Logistic回归分析CHF并发心律失常患者预后不良的影响因素.采用受试者工作特征(ROC)曲线分析血清GGT、Gal-3对CHF并发心律失常患者预后不良的预测价值.结果 研究组血清GGT、Gal-3水平高于CHF组、对照组,CHF组血清GGT、Gal-3水平高于对照组,差异均有统计学意义(P<0.05).与预后良好组相比,预后不良组GGT、Gal-3、BNP水平明显升高(P<0.05),LVEF明显降低(P<0.05).BNP、LVEF、GGT、Gal-3为CHF并发心律失常患者预后不良的影响因素(P<0.05).血清GGT、Gal-3预测CHF并发心律失常患者预后不良的曲线下面积(AUC)分别为0.836、0.848,2项指标联合预测的AUC为0.925,显著大于各单一指标的AUC(Z联合-GGT=2.071,P=0.038;Z联合-Gal-3=2.185,P=0.029).结论 CHF并发心律失常患者血清GGT、Gal-3水平升高,均为患者预后不良的危险因素,2项指标联合对CHF并发心律失常患者预后不良具有较高的预测价值.
Objective To investigate the predictive value of serum γ-glutamyltransferase(GGT)and galec-tin-3(Gal-3)for poor prognosis in patients with chronic heart failure(CHF)complicated by arrhythmia.Methods A total of 121 patients with CHF complicated by arrhythmia admitted to Chuzhou First People's Hospital from June 2022 to January 2024 were selected as the study group.Based on their prognosis,these pa-tients were further divided into a poor-prognosis subgroup and a good-prognosis subgroup.Additionally,121 patients with CHF alone and 121 healthy individuals undergoing physical examinations during the same period were selected as the CHF group and the control group respectively.Serum levels of GGT and Gal-3 among the groups,along with cardiac function parameters[brain natriuretic peptide(BNP)and left ventricular ejection fraction(LVEF)],were compared between the poor-prognosis group and good-prognosis group.Multivariate Logistic regression analysis was used to identify influencing factors for poor prognosis in patients with CHF complicated by arrhythmia.Receiver operating characteristic(ROC)curve was utilized to analyze the predic-tive value of serum GGT and Gal-3 for poor prognosis.Results Serum levels of GGT and Gal-3 in the study group were significantly higher than those in the CHF and control groups,and levels in the CHF group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).Compared with the good-prognosis subgroup,levels of GGT,Gal-3 and BNP were significantly elevated(P<0.05),whereas LVEF was significantly reduced in the poor-prognosis subgroup(P<0.05).BNP,LVEF,GGT,and Gal-3 were identified as influencing factors for poor prognosis in patients with CHF compli-cated by arrhythmia(P<0.05).The areas under the curve(AUCs)for serum GGT and Gal-3 in predicting poor prognosis were 0.836 and 0.848 respectively.The AUC for the combined prediction was 0.925,which was significantly greater than that of each individual indicator(Zcombination vs.GGT=2.071,P=0.038;Zcombination vs.Gal-3=2.185,P=0.029).Conclusion Elevated serum levels of GGT and Gal-3 in patients with CHF complicated by arrhythmia are both risk factors for poor prognosis.The combination of these two biomarkers demonstrates high predictive value for poor prognosis in such patients.
刘玉;吴频霞;徐小红;刘亚圆;杨诺言
安徽医科大学附属滁州医院心血管内科,安徽 滁州 239000安徽省滁州市第一人民医院南区康复医学科,安徽 滁州 239000安徽省滁州市第一人民医院心血管内科,安徽 滁州 236031安徽省滁州市第一人民医院心血管内科,安徽 滁州 236031蚌埠医科大学临床学院,安徽 蚌埠 233030
医药卫生
慢性心力衰竭心律失常γ-谷氨酰转移酶半乳糖凝集素-3预后
chronic heart failurearrhythmiaγ-glutamyltransferasegalectin-3prognosis
《检验医学与临床》 2026 (6)
809-814,821,7
安徽省滁州市科技计划项目(2023ZD034).
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