原发性衰老相关性tau蛋白病和阿尔茨海默病早期阶段的样本分析OA

Objective:To investigate the pathologic changes of primary age-related tauopathy(PART)and early stage of Alzheimer's disease(pre-AD)in Chinese human brain samples,with the aim to provide a basis for the clinical diagnosis and pathological classification.Methods:Demographic,anatomical,neuropathological,and clinical data of PART and pre-AD samples were collected,and pathological diagnosis was performed through various morphological staining methods including hematoxylin-eosin(H-E)staining,special staining and immunohistochemistry,followed by statistical analysis of relevant data.Results:There were statistically significant differences between the PART and pre-AD groups in the pathological changes of cerebral amyloid angiopathy(CAA).CAA was present in only one case in the PART group,while the proportion of the pre-AD group reached 25.9%.The expression rates of TDP43 and p62 in the pre-AD group were higher than those of the PART group.No statistically significant differences were found between the groups in brain weight,cerebrospinal fluid pH,or Braak stage.Conclusion:Differences in certain pathologic indicators between PART and pre-AD in Chinese brain samples may be related to age at death.