基于"因加而发"探讨慢性萎缩性胃炎"炎癌转化"病机与防治OA

Chronic atrophic gastritis(CAG)is a common gastrointestinal disorder characterized by insidious onset,complex pathogeneses,and a tendency to be difficult to treat.The dynamic pathological progression of"superficial gastritis--atrophic gastritis--intestinal metaplasia--intraepithelial neoplasia--gastric cancer"represents the process of"inflammation-to-cancer transformation"in the stomach.The theory"exacerbation due to additional pathogenic factors"recorded in the Inner Canon of Yellow Emperor is one of the common pathogeneses by which diseases occur in the human body.It refers to the fact that the potential pathogenic factors in the body are suppressed by the body's healthy qi and the person does not get sick.However,these latent factors remain present in the body.When the body is then exposed to new pathogenic factors,the combination of these old and new factors overwhelms the body's healthy qi,which is no longer able to contain the pathogens,leading to the onset of diseases.This view that both old and new pathogenic factors jointly disturb the body and cause it to lose its original state of balance,leading to the development of diseases,is consistent with the pathological progression of inflammation-to-cancer transformation in CAG.Exploring the pathogenesis of CAG's inflammation-to-cancer transformation based on the"exacerbation due to additional pathogenic factors"theory provides an important guidance for delaying or even reversing the progression of CAG to gastric cancer.