射麻口服液联合噻托溴铵在慢性阻塞性肺疾病急性加重期痰热壅肺证患者中的应用效果OA
Application effect of Shema Oral Liquid combined with Tiotropium Bro-mide in patients with phlegm-heat obstructing lung syndrome in the acute exacerbation stage of chronic obstructive pulmonary disease
目的 探究射麻口服液联合噻托溴铵治疗慢性阻塞性肺疾病急性加重期(AECOPD)痰热壅肺证患者疗效及对心肺功能、炎症状态的影响.方法 选取 2022 年 10 月至 2024 年4 月在九江第一人民医院开发区分院确诊为AECOPD痰热壅肺证的 80 例患者作为研究对象,采用随机数字表法分为对照组和观察组,各 40 例.对照组在标准化治疗的基础上使用噻托溴铵治疗,观察组在对照组的基础上加用射麻口服液治疗.比较两组临床疗效、中医证候量化评分、心功能指标、肺功能指标、炎症反应指标及不良反应发生率的差异.结果 观察组治疗总有效率高于对照组,差异有统计学意义(P＜0.05).两组中医证候量化评分、心功能指标、肺功能指标及炎症反应指标均呈现出显著的时间效应、组间效应及时间与组间的交互效应;观察组中医证候量化评分、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、右心室收缩末期内径(RVESD)、高迁移率族蛋白B1(HMGB1)、降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)均低于对照组,观察组左心室射血分数(LVEF)、右心室射血分数(RVEF)、峰值流速(PEF)、用力肺活量(FVC)、第 1 秒用力呼气容积(FEV1)、FEV1/FVC均高于对照组,差异有统计学意义(P＜0.05).两组不良反应总发生率比较,差异无统计学意义(P＞0.05).结论 射麻口服液联合噻托溴铵治疗AECOPD痰热壅肺证,能够有效提高临床治疗的总有效率,促进心肺功能的恢复,减轻炎症反应,在安全性上与单独使用噻托溴铵相当.
Objective To explore the therapeutic effect of Shema Oral Liquid combined with Tiotropium Bromide in the treatment of phlegm-heat obstructing lung syndrome in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and its influence on cardiopulmonary function and inflammation.Methods A total of 80 patients diag-nosed with phlegm-heat obstructing lung syndrome of AECOPD in Jiujiang First Peo ple's Hospital Development Zone Branch from October 2022 to April 2024 were selected and divided into control group and observation group by random number table method,with 40 cases in each group.The control group was treated with Tiotropium Bromide on the basis of standardized treatment,and the observation group was treated with Shema Oral Liquid on the basis of control group.The differences of clinical efficacy,traditional Chinese medicine syndrome quantitative score,heart function index,lung function index,inflammatory response index and incidence of adverse reactions were compared between the two groups.Results The total effective rate of observation group was higher than that of control group;the quantitative score of traditional Chinese medicine syndrome,heart function index,lung function in-dex and inflammatory response index of 2 groups showed significant time effect,intergroup effect and interaction ef-fect between time and group;the traditional Chinese medicine syndrome quantification scores,left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),right ventricular end-systolic diameter(RVESD),high mobility group protein B1(HMGB1),procalcitonin(PCT)and tumor necrosis factor-α(TNF-α)in observation group were lower than those in control group;left ventricular ejection fraction(LVEF),right ventricular ejection fraction(RVEF),peak flow velocity(PEF),forced vital capacity(FVC),forced expiratory volume in one second(FEV1)and FEV1/FVC in observation group were higher than those in control group,and the differences were statistically significant(P＜0.05).There was no sta-tistically significant difference in the overall incidence of adverse reactions between the two groups(P＞0.05).Conclusion Shema Oral Liquid combined with Tiotropium Bromide in the treatment of AECOPD syndrome of phlegm heat obstruction can effectively improve the total effective rate of clinical treatment,promote the recovery of cardiopulmonary function,reduce inflammation,and have the same safety as tiotropium bromide alone.
章秀;汪聪聪;熊琪;王浩霞;胡跞天;徐兰芳
江西省九江第一人民医院开发区分院呼吸科,江西 九江 332000江西省九江第一人民医院开发区分院呼吸科,江西 九江 332000江西省九江第一人民医院开发区分院呼吸科,江西 九江 332000江西省九江第一人民医院开发区分院呼吸科,江西 九江 332000江西省九江第一人民医院开发区分院检验科,江西 九江 332000江西省九江第一人民医院开发区分院心超室,江西 九江 332000
医药卫生
射麻口服液噻托溴铵慢性阻塞性肺疾病急性加重期痰热壅肺证临床疗效
Shema Oral LiquidTiotropium BromideAcute exacerbation of chronic obstructive pulmonary diseaseSyn-drome of phlegm-heat obstructing lungClinical effect
《中国当代医药》 2026 (4)
44-49,6
江西省卫生健康委科技计划项目(202211891).
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