血流感染产超广谱β-内酰胺酶大肠埃希菌的影响因素及耐药性分析OA

Objective To analyze the infection status,drug resistance characteristics,and risk factors of extended-spectrum β-lactamases(ESBLs)-producing Escherichia coli in bloodstream infections in Chongqing Hospital,Jiangsu Provincial People's Hospital,and provide scientific basis for early clinical diagnosis and treatment of bloodstream infections.Methods A retrospective analysis was conducted on the clinical data of 124 hospitalized patients with bloodstream infections caused by Escherichia coli admitted to Chongqing Hospital,Jiangsu Provincial People's Hospital from August 2023 to August 2025.The patients were divided into ESBLs-producing group and non-ESBLs-producing group based on whether they were ES-BLs producing or not.The results of two drug susceptibility tests were analyzed and compared.The risk factors for ESBLs production in Escherichia coli infected with influenza were analyzed.Results Among 124 patients,67 cases(54.03%)had ESBLs-producing Escherichia coli infections and 57 cases(45.97%)had non-ESBLs-producing ones.In the ESBLs-pro-ducing group,the resistance rates to Cefazolin and Cefotaxime were 100%,and those to six other antibiotics like Ceftriaxone exceeded 80%.Resistance rates to 12 antibiotics in this group were higher than those of the non-ESBLs-producing group(P＜0.05).Univariate and multivariate logistic regression showed that invasive catheterization,hospitalization within 90 days before infection,surgery within 30 days before infection,and use of Beta-lactam/Enzyme Inhibitor antibiotics were independent risk factors for bloodstream infections caused by ESBLs-producing Escherichia coli(P＜0.05).Conclusion The detection rate and drug resistance rate of ESBLs producing Escherichia coli in our hospital's blood influenza infection are relatively high,which should be taken seriously.In clinical treatment,special attention should be paid to drug sensitivity testing for patients with independent risk factors.