核壳型铜铁银纳米复合材料的杀菌活性研究OA

Infections caused by pathogenic microorganisms have emerged as a major threat to global public health,the ecological environment,and economic stability.In particular,owing to the widespread misuse of conventional organic antibiotics,the continuous emergence of multidrug-resistant bacteria poses severe challenges to existing prevention and treatment strategies.To that end,this study constructed a CuFe2O4 nanocarrier via a one-pot method and,through surface-modification strategies,uniformly loaded ultrasmall silver nanoparticles onto its surface to prepare a CuFe2O4@Ag nanocomposite with a core-shell structure.This architecture not only effectively inhibits the aggregation of silver nanoparticles but also enables the continuous generation of reactive oxygen species(ROS)such as·OH and 1O2 under aerobic conditions via a Fenton-like reaction,which synergizes with released metal ions such as Cu2+,Fe3+,and Ag+to exert bactericidal effects.Experimental results showed that CuFe2O4@Ag exhibits excellent antibacterial activity against Escherichia coli,Staphylococcus aureus,and methicillin-resistant Staphylococcus aureus,with a sterilization rate exceeding 99.99％achieved within 15 min.Mechanistic studies revealed that the released metal ions and ROS function synergistically to irreversibly disrupt the negatively charged environment of bacterial cell walls.This neutralizes surface charges,compromises the cell-membrane integrity,and induces the leakage of intracellular plasmids,nucleic acids,and key ions,thus ultimately resulting in bacterial death.The CuFe2O4@Ag nanocomposite demonstrates rapid,broad-spectrum,and highly efficient antibacterial performance,thereby showcasing its significant application potential in medical-device surface protection and anti-infective materials.