碱促进下2,3-二取代苯并呋喃的高效合成OA

Benzofuran is a heterocyclic structural unit that occurs widely in natural products,drugs,pesticides,and functional materials,and it is used as a potential synthetic building block in preparing various biologically active molecules.The synthesis of benzofuran cores is well-established,but efficient general methods of synthesizing 2,3-disubstituted benzofurans remain relatively limited.Several reported methods often suffer from challenges,such as harsh reaction conditions,cumbersome steps,and poor substrate generalities,and thus,developing a facile,mild,efficient,operationally simple synthetic method is necessary.This study designed a method of synthesizing 2,3-disubstituted benzofuran derivatives using easily prepared o-hydroxychalcones and commercially available γ-bromocrotonates as starting materials.The reaction proceeded via a one-pot multistep tandem process under mildly basic conditions.This strategy avoided the use of expensive metal catalysts and harsh reaction conditions,demonstrating a good functional-group compatibility and operational simplicity.This synthetic strategy provided a novel approach for use in efficiently synthesizing 2,3-disubstituted benzofuran derivatives.It also laid a solid foundation for further in-depth research into their biological activities and material properties,displaying potential for application in the fields of medicinal chemistry and organic synthesis.