首页|期刊导航|骨研究(英文版)|Modeling the chondrocyte-derived osteoblasts formation process reveals its molecular signature and regulation network

Modeling the chondrocyte-derived osteoblasts formation process reveals its molecular signature and regulation networkOA

Modeling the chondrocyte-derived osteoblasts formation process reveals its molecular signature and regulation network

Raquel Ruiz-Hernández;Maria M.Caffarel;Daniela Gerovska;Marcos J.Araúzo-Bravo;Amaia Vilas;Felipe Prosper;Sergio Moya;Daniel Alonso-Alconada;Ana Alonso-Varona;Gretel Nusspaumer;Javier Lopez-Rios;Laurie Gay;Karine Rizotti;Robin Lovell-Badge;Dominique Bonnet;Ilaria Malanchi;Ander Abarrategi;Verónica Moncho-Amor;Pablo Martín;Jhonatan A.Vergara-Arce;Stefania Di Blasio;Thomas Snoeks;Unai Cossío;Ander Matheu

Department of Cell Biology and Histology,Faculty of Medicine and Nursing,University of Basque Country(UPV/EHU),Leioa,Spain||Center for Cooperative Research in Biomaterials(CIC biomaGUNE),Basque Research and Technology Alliance(BRTA),Donostia-San Sebastian,SpainBiogipuzkoa Health Research Institute,San Sebastián,Spain||IKERBASQUE,Basque Foundation for Science,Bilbao,SpainBiogipuzkoa Health Research Institute,San Sebastián,SpainDepartment of Cell Biology and Histology,Faculty of Medicine and Nursing,University of Basque Country(UPV/EHU),Leioa,Spain||Biogipuzkoa Health Research Institute,San Sebastián,Spain||IKERBASQUE,Basque Foundation for Science,Bilbao,SpainDepartment of Hematology-Oncology,Instituto de Investigación Sanitaria de Navarra(IDISNA),CIMA Universidad de Navarra,Pamplona,SpainDepartment of Hematology-Oncology,Instituto de Investigación Sanitaria de Navarra(IDISNA),CIMA Universidad de Navarra,Pamplona,Spain||Centro de Investigación Biomédica en Red de Cáncer,CIBERONC,Instituto de Salud Carlos III,Madrid,SpainCenter for Cooperative Research in Biomaterials(CIC biomaGUNE),Basque Research and Technology Alliance(BRTA),Donostia-San Sebastian,SpainDepartment of Cell Biology and Histology,Faculty of Medicine and Nursing,University of Basque Country(UPV/EHU),Leioa,SpainDepartment of Cell Biology and Histology,Faculty of Medicine and Nursing,University of Basque Country(UPV/EHU),Leioa,SpainCentro Andaluz de Biología del Desarrollo(CABD),CSIC-Universidad Pablo de Olavide-Junta de Andalucía,Seville,SpainCentro Andaluz de Biología del Desarrollo(CABD),CSIC-Universidad Pablo de Olavide-Junta de Andalucía,Seville,SpainTumour-Host Interaction Laboratory,The Francis Crick Institute,London,UKStem Cell Biology and Developmental Genetics Laboratory,The Francis Crick Institute,London,UKStem Cell Biology and Developmental Genetics Laboratory,The Francis Crick Institute,London,UKHaematopoietic Stem Cell Laboratory,The Francis Crick Institute,London,UKTumour-Host Interaction Laboratory,The Francis Crick Institute,London,UKDepartment of Cell Biology and Histology,Faculty of Medicine and Nursing,University of Basque Country(UPV/EHU),Leioa,Spain||Center for Cooperative Research in Biomaterials(CIC biomaGUNE),Basque Research and Technology Alliance(BRTA),Donostia-San Sebastian,SpainStem Cell Biology and Developmental Genetics Laboratory,The Francis Crick Institute,London,UK||Biogipuzkoa Health Research Institute,San Sebastián,SpainDepartment of Cell Biology and Histology,Faculty of Medicine and Nursing,University of Basque Country(UPV/EHU),Leioa,Spain||Center for Cooperative Research in Biomaterials(CIC biomaGUNE),Basque Research and Technology Alliance(BRTA),Donostia-San Sebastian,SpainCenter for Cooperative Research in Biomaterials(CIC biomaGUNE),Basque Research and Technology Alliance(BRTA),Donostia-San Sebastian,SpainTumour-Host Interaction Laboratory,The Francis Crick Institute,London,UK||Laboratory of Cancer Pathology,Center for Advanced Studies and Technology(CAST),University"G.D'Annunzio",Chieti,ItalyBiological Research Facility,The Francis Crick Institute,London,UKCenter for Cooperative Research in Biomaterials(CIC biomaGUNE),Basque Research and Technology Alliance(BRTA),Donostia-San Sebastian,SpainBiogipuzkoa Health Research Institute,San Sebastián,Spain||IKERBASQUE,Basque Foundation for Science,Bilbao,Spain||Centro de Investigación Biomédica de fragilidad y envejecimiento,CIBERFES,Instituto de Salud Carlos III,Madrid,Spain

《骨研究(英文版)》 2026 (1)

291-302,12

The authors would like to thank the staff at CIC biomaGUNE core facility platforms.This work was funded by Grants PID2021-127191OB-I00,RTI2018-101708-A-I00,PRE2018-084542 and PRE2022-102680 funded by MCIN/AEI/10.13039/501100011033 and by"ERDF A way of making Europe".Grant RYC2018-025502-I is funded by MCIN/AEI/10.13039/501100011033 and by"ESF Investing in your future".Grant MDM-2017-0720 Maria de Maeztu Units of Excellence Program funded by the Spanish State Research Agency.D.G.and M.J.A.-B.were supported by Instituto de Salud Carlos III,Infrastructure of Precision Medicine associated with Science and Technology(IMPaCT)of the Strategic Action in Health(iDATA-MP).

10.1038/s41413-025-00500-6

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