血管性认知障碍患者脑铁沉积和血清铁代谢与认知障碍的相关性研究OA

Objective:To investigate the correlation between the cognitive impairment of vascular cognitive impairment(VCI)patients and brain iron deposition and serum iron metabolism indexes,and to clarify the mechanism of cognitive impairment of VCI.Methods:A total of 42 patients with VCI and 21 age-,gender-,and education-matched healthy controls were enrolled in this study.Montreal Cognitive Assessment(MoCA),Mini-mental State Examination(MMSE),Modified Barthel Index(MBI),and Clinical Dementia Rating(CDR)were used to assess cognitive function;magnetic resonance magnetic susceptibility-weighted imaging(SWI)was used to check the signal intensity values of bilateral caudate nucleus,putamen,globus pallidus,thalamus,red nucleus,substantia nigra,and hippocampus in the brain;Enzyme-linked immunosorbent assay was used to detect serum iron metabolism indicators such as serum iron,ferritin,transferrin,total iron-binding capacity,and hemoglobin levels.The differences of SWI iron deposition and serum iron metabolism indexes between VCI patients and healthy controls were analyzed,and their correlations with cognitive function MoCA and MMSE scale scores were also analyzed.Results:There were no significant differences in age,gender,and baseline education between the two groups(P>0.05).The MoCA,MMSE,MBI,and CDR scores of the VCI patients were significantly lower than those of the healthy controls(P<0.05).There were significant differences in SWI signal intensity values in the left putamen,right substantia nigra,and left hippocampus between the VCI pa-tients and the healthy controls(P<0.05),and the SWI signal intensity value in the left hippocampus of the VCI patients was posi-tively correlated with the total score of MoCA(r=0.311,P=0.045).There were significant differences in serum iron,serum fer-ritin,serum transferrin,and total iron binding capacity between the VCI patients and the healthy controls(P<0.05),and the se-rum ferritin level of VCI patients was negatively correlated with the total score of MoCA(r=-0.566,P<0.001),suggesting that cognitive impairment in the VCI patients was associated with increased iron deposition in the left hippocampus and increased serum ferritin level.Conclusion:Iron homeostasis imbalance may be an important pathological mechanism of VCI,mainly mani-fested by increased iron deposition in the central nervous system and increased serum ferritin level.