多囊卵巢综合征患者血清SAA1、PTX3表达与胰岛素抵抗的相关性OA

Objective To investigate the correlation between serum amyloid A1(SAA1)and pentraxin-3(PTX3)expression and insulin resistance(IR)in patients with polycystic ovary syndrome(PCOS).Methods From May 2022 to April 2024,179 PCOS patients who received treatment in Leshan Maternal and Child Health Hospital were included as the study group.According to the homeostasis model assessment of insulin resistance(HOMA-IR),they were grouped into a combined IR group of 83 cases and a non-IR group of 96 cases.Meanwhile,95 healthy individuals who underwent physical examinations were selected as the control group.Enzyme-linked immunosorbent assay(ELISA)method was applied to detect serum levels of SAA1 and PTX3.The clinical factors such as fasting blood glucose(FBG)and fasting insulin(FINS)were detected.Pearson correlation was applied to analyze the correlation between serum SAA1 and PTX3 levels and IR-related indicators in the combined IR group.Logistic regression was applied to analyze the influencing factors of IR in PCOS patients.The receiver operating characteristic(ROC)curve was applied to analyze the predictive value of the model.Results Compared with the control group,the expression levels of SAA1 and PTX3 in the study group were increased,and the difference was statistically significant(t=12.696,11.541,P<0.05);the BMI,FBG,FINS,HOMA-IR,SAA1 and PTX3 in the combined IR group were higher than those in the non-IR group,and the difference was statistically significant(t values ranged from 2.758 to 17.212,P<0.05);the expression levels of serum SAA1 and PTX3 in the combined IR group were positively correlated with the BMI,FBG,FINS and HOMA-IR indicators(r values ranged from 0.412 to 0.532,P<0.05).Multivariate logistic regression analysis showed that SAA1,and PTX3 were risk factors for IR occurrence in PCOS patients(OR=2.189,1.547,P<0.05).The area under the curve(AUC)for predicting IR occurrence in PCOS patients by serum SAA1 and PTX3 levels was 0.788 and 0.793 respectively.The AUC for the combined prediction was 0.880,which was significantly higher than that of the individual predictions of SAA1 and PTX3(Z=2.110,2.071,P<0.05).Conclusion The expression levels of serum SAA1 and PTX3 in PCOS patients are significantly elevated.The expression levels of serum SAA1 and PTX3 in PCOS patients combined with IR are significantly higher than those in the non-IR group.The detection of serum SAA1 and PTX3 levels may be used for evaluating disease status of PCOS patients and PCOS patients with IR.