围绝经期女性抑郁情绪调查及与肠道菌群平衡的相关性分析OA

Objective To investigate depression emotion in perimenopausal women and its correlation with intestinal flora balance.Methods A total of 328 perimenopausal women who underwent physical examination in Physical Examination Center of The Second Hospital of Hebei Medical University from May 2021 to June 2023 were selected as study subjects.They were divided into depression group and non-depression group according to whether the perimenopausal woman had depression emotion.General information questionnaire,Perceived Stress Scale(PSS),Self-rating Depression Scale(SDS),Simplified Coping Style Questionnaire(SCSQ),Connor-Davidson Resilience Scale(CD-RISC),Modified Kupperman Rating Scale,Perceived Social Support Scale(PSSS),and abdominal distension scoring were used for investigation and analysis.Lasso regression and Logistic regression equation analyses were used to analyze influencing factors of depression emotion in perimenopausal women.Spearman correlation was used to analyze correlation between intestinal flora balance and depression emotion.Results The incidence of depression emotion in perimenopausal women was 31.40%(103/328).High social support level,positive SCSQ score>22.20 points,CD-RISC score>82.14 points,serum 5-hydroxytryptamine(5-HT)level>0.92 ng/mL,and serum estradiol level>135.46 pmol/L were protective factors for occurrence of depression emotion in perimenopausal women(OR=0.316-0.990,all P<0.05).Excessive perceived stress level,negative SCSQ score>15.12 points and severe perimenopausal symptoms were risk factors for occurrence of depression emotion in perimenopausal women(OR=3.882-6.169,all P<0.05).The bifidobacterium value in the depression group was lower than that in the non-depression group,and the enterobacterium value and score in abdominal distension were higher than those in the non-depression group,and the differences were statistically significant(t=7.454-17.705,all P<0.05).Bifidobacterum value was negatively correlated with depression mode,while enterobacterium value and abdominal distension score were positively correlated with depression emotion(r=-0.621,0.614 and 0.724 respectively,all P<0.05).Conclusion The incidence of depression emotion in perimenopausal women is high.Social support level,perceived stress level,coping style,severity of perimenopausal symptoms,serum estradiol and 5-HT levels are influencing factors of depression emotion in perimenopausal women.Perimenopausal depression emotion is negatively correlated with bifidobacterum value,and positively correlated with Enterobacterium value and abdominal distension score.Clinically,relevant countermeasures can be formulated accordingly to ensure the physical and mental health of perimenopausal women.