黄芩苷抗菌水凝胶的制备、表征及药理活性分析OA

In addressing the inadequate water solubility and bioavailability of baicalin,this study develops a drug carrier that exhibits both antimicrobial and self-healing hydrogel by integrating konjac glucomannan(KGM)-based hydrogel with cyclodextrin encapsulation technology.The successful preparation of baicalin/hydroxypropyl-β-cyclodextrin inclusion complexes is achieved through the utilisation of a saturated solution stirring-freeze-drying method.Subsequent FTIR and XRD analysis demonstrates the effective inclusion of baicalin within the cyclodextrin cavity.The inclusion complexes are loaded into KGM/sodium tetraborate dynamically crosslinked hydrogels,and the resulting hydrogels exhibit excellent swelling properties with a swelling rate of 630.23%.Mechanical tests demonstrate that the hydrogel has significant self-healing capability,with a tensile strength retention rate of 97.80%after healing.In vitro release experiments demonstrate that the system conforms to First-order release model,the cumulative release rate of baicalin reaches 84.33%at 48 h.Antimicrobial experiments confirm that its inhibition rate against Staphylococcus aureus,Escherichia coli and Candida albicans reaches 99.12%,98.07%and 98.82%,respectively,and the DPPH radical scavenging rate is as high as 93.54%.This study proposes a viable methodology for the development of innovative antimicrobial materials and drug carriers,addressing the challenges of low solubility and poor stability associated with baicalin.