抗逆转录病毒治疗相关的HIV感染者脑功能动态改变OA
Antiretroviral Therapy-related Alteration of Brain Functional Dynamics in People with HIV
为了调查与抗逆转录病毒治疗(antiretroviral therapy,ART)相关的静息状态功能连接的动态特性,从 45名接受治疗的HIV感染者(people with HIV,PWH)、56 名未接受治疗的PWH与68 名健康对照者采集得到功能磁共振成像数据.使用组独立成分分析、滑动窗分析提取窗功能连接矩阵及量化其动态特性.结果表明,基线状态、弱激活状态体现了HIV相关异常动态及ART相关恢复,弱激活状态体现小脑相关连接恢复、壳核相关功能代偿,基线状态体现除视觉网络外的广泛网络连接恢复.视觉相关连接在两种状态中均体现为ART相关的不良反应.这些发现表明小脑、壳核可能是ART相关恢复的敏感生物标志物,视觉网络可作为辅助治疗的目标.
To investigate the dynamic properties of resting-state functional connectivity associated with antiretroviral therapy(ART),functional magnetic resonance imaging data from 45 treated people with HIV(PWH),56 untreated PWH,and 68 healthy controls were collected.Group independent component analysis and sliding window analysis were conducted to obtain window-functional connectivity matrices,and their dynamic properties were quantified.The results showed that the baseline state and the weakly activated state reflect HIV-related abnormal dynamics and ART-related recovery.The weakly activated state reflected the recovery of cerebellum-related connections and putamen-related functional compensation.The baseline state reflected the recovery of extensive connections except for the visual network.Visual-related connections reflected ART-related adverse reactions in both states.These findings suggest that the cerebellum and putamen may be sensitive biomarkers for ART-related recovery,and the visual network can serve as a target for adjuvant therapy.
王奕雯;吴光耀;文之;林富春
磁共振波谱与成像全国重点实验室,武汉国家磁共振中心,中国科学院精密测量科学与技术创新研究院,湖北 武汉 430071||中国科学院大学,北京 100049武汉大学中南医院放射科,湖北 武汉 430071||深圳大学总医院放射科,广东 深圳 518055武汉大学中南医院放射科,湖北 武汉 430071||武汉大学人民医院放射科,湖北 武汉 430060磁共振波谱与成像全国重点实验室,武汉国家磁共振中心,中国科学院精密测量科学与技术创新研究院,湖北 武汉 430071||中国科学院大学,北京 100049
数理科学
人类免疫缺陷病毒抗逆转录病毒治疗功能磁共振成像动态功能连接
HIVantiretroviral therapy(ART)functional magnetic resonance imaging(fMRI)dynamic functional connectivity(dFC)
《波谱学杂志》 2026 (1)
61-70,10
国家自然科学基金资助项目(82472060)中国科学院前沿科学重大突破项目(QYZDB-SSW-SLH046).
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