脐血中性粒细胞载脂蛋白水平与胎膜早破母亲分娩新生儿围生期感染关系的研究OA

Objective:To investigate the expression level of umbilical cord blood neutrophil gelatinase-associated lipocalin(NGAL,also known as HNL)in neonates born to mothers with premature rupture of membranes(PROM),and its relationship with neonatal perinatal infection.Methods:A total of 70 neonates born to PROM mothers hospitalized in the Department of Obstetrics of our hospital from January 2023 to December 2024 were enrolled and divided into an infection group(n=15)and a control group(n=55)according to the occurrence of neonatal infection.The expression level of HNL in umbilical cord blood was detected by enzyme-linked immunosorbent assay(ELISA).Multivariate Logistic regression analysis was used to explore the risk factors of perinatal infection in neonates born to PROM mothers.The predictive value of serum HNL for perinatal infection in these neonates was analyzed by receiver operating characteristic(ROC)curve.Results:The proportion of duration from PROM to delivery≥12 h,and the levels of WBC,CRP,PCT and HNL in the infection group were significantly higher than those in the control group(P<0.05).High levels of CRP,PCT and HNL were independent risk factors for perinatal infection in neonates born to PROM mothers(P<0.05).The AUC of serum HNL alone in predicting perinatal infection was 0.946,which was higher than 0.836 of CRP and 0.828 of PCT.The AUC of the combined detection of the three indicators was 0.962,which was higher than that of each single indicator(P<0.05).Conclusion:The expression level of HNL in umbilical cord blood is increased in PROM-related neonatal perinatal infection,and it has a certain predictive value for the occurrence of neonatal infection.