不同卒中类型吞咽困难患者吞咽状态下皮层网络之间的功能连接:一项功能性近红外光谱研究OA

Objective:To use functional near-infrared spectroscopy(fNIRS)to investigate the differences and characteristics of cortical correlation and functional connectivity of brain networks during voluntary swallowing in healthy adults and dysphagia patients with different stroke types.Methods:Ten healthy volunteers and 20 post-stroke patients with dysphagia were enrolled.fNIRS signals and baseline data were recorded during voluntary swallowing.According to the time-series concentrations of oxyhemoglobin and deoxyhemoglobin,the average whole-brain functional connectivity strength was calculated in different stroke subgroups and healthy controls.Intergroup differences were compared across 8 regions of interest(ROIs).Results:During voluntary swallowing,functional connectivity strength was decreased to various degrees in all patient groups compared with healthy adults(0.56±0.05).Patients with brainstem infarction showed the lowest value(0.24±0.12),followed by ischemic stroke patients(0.29±0.10)and hemorrhagic stroke patients(0.37±0.06).No significant difference in whole-brain functional connectivity was found between hemorrhagic and ischemic stroke patients(P>0.05).Significant differences were detected between hemorrhagic stroke and brainstem infarction groups in the connectivity of middle motor cortex-left prefrontal cortex and middle motor cortex-right prefrontal cortex(P<0.05).Ischemic stroke and brainstem infarction groups differed significantly in middle motor cortex-left prefrontal cortex connectivity(P<0.05).Most ROI-based functional connectivity strengths differed significantly between patients and healthy adults(P<0.05).Conclusion:Healthy adults present obvious whole-brain functional connectivity during voluntary swallowing.By contrast,post-stroke dysphagia patients show reduced functional connectivity strength to varying degrees.