甘氨酸龈下喷砂治疗2型糖尿病合并牙周炎患者疗效及对牙菌斑指数和龈沟液炎症因子水平的影响OA
Efficacy of Glycine Subgingival Air Polishing in Patients with Type 2 Diabetes Mellitus and Periodontitis and Its Effects on Plaque Index and Inflammatory Factor Levels in Gingival Crevicular Fluid
目的 探讨甘氨酸龈下喷砂治疗2型糖尿病(T2DM)合并牙周炎患者的疗效及对菌斑指数(PLI)和龈沟液炎症因子水平的影响.方法 选择2023年6月至2024年12月河北医科大学第三医院诊治的T2DM合并牙周炎患者80例,采用简单随机法(随机数表)分为常规组和喷砂组,每组40例.常规组采用传统超声联合手动龈下刮治根面平整治疗,喷砂组采用甘氨酸龈喷砂治疗.以基础牙周治疗后1个月为基线,比较两组基线及维护治疗1、3、6个月探诊出血指数(BI)、探诊深度(PD)、PLI、咀嚼功能(咬合力、咀嚼效率),基线、维护治疗1个月糖脂指标[糖化血红蛋白(HbAlc)、三酰甘油(TG)、总胆固醇(TC)、空腹血糖(FPG)]、龈沟液炎症因子[肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)、白细胞介素6(IL-6)]水平.结果 与基线比较,维护治疗1、3、6个月,两组BI、PD、PLI均显著下降(P<0.05),且喷砂组均显著低于常规组(P<0.05).与基线比较,维护治疗1、3、6个月,两组咬合力、咀嚼效率均显著升高(P<0.05),且喷砂组均显著高于常规组(P<0.05).维护治疗1个月,两组HbAlc、TG、TC、FPG水平及TNF-α、CRP、IL-6水平均显著下降(P<0.05),且喷砂组均低于常规组(P<0.05).结论 甘氨酸龈下喷砂可有效治疗T2DM合并牙周炎,改善牙周健康和咀嚼功能,降低血糖、血脂水平,并缓解牙龈炎症反应.
Objective To investigate the efficacy of glycine subgingival air polishing in the treatment of patients with type 2 diabetes mellitus(T2DM)and periodontitis and its effects on plaque index(PLI)and the levels of inflammatory factors in gingival crevicular fluid.Methods From June 2023 to December 2024,80 patients with T2DM and periodontitis diagnosed and treated at the Third Hospital of Hebei Medical University were selected and divided into a conventional group and an air polishing group using a simple randomization method(random number table),with 40 cases in each group.The conventional group received traditional ultrasonic scaling combined with manual subgingival scaling and root planing,while the air polishing group received glycine subgingival air polishing.Taking 1 month after initial periodontal therapy as the baseline,bleeding index(BI),probing depth(PD),PLI,and masticatory function(bite force,masticatory efficiency)were compared between the two groups at baseline and at 1,3,and 6 months of maintenance therapy.Glycemic and lipid parameters[glycated hemoglobin(HbA1c),triglyceride(TG),total cholesterol(TC),fasting blood glucose(FPG)]and gingival crevicular fluid inflammatory factors[tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6)]were compared at baseline and at 1 month of maintenance therapy.Results Compared with baseline,BI,PD,and PLI in both groups decreased significantly at 1,3,and 6 months of maintenance therapy(P<0.05),and all were significantly lower in the air polishing group than in the conventional group(P<0.05).Compared with baseline,bite force and masticatory efficiency in both groups increased significantly at 1,3,and 6 months of maintenance therapy(P<0.05),and both were significantly higher in the air polishing group than in the conventional group(P<0.05).At 1 month of maintenance therapy,the levels of HbA1c,TG,TC,FPG,TNF-α,CRP,and IL-6 decreased significantly in both groups(P<0.05),and all were lower in the air polishing group than in the conventional group(P<0.05).Conclusion Glycine subgingival air polishing can effectively treat periodontitis in patients with T2DM,improve periodontal health and masticatory function,reduce blood glucose and lipid levels,and alleviate gingival inflammatory response.
司伟;侯晓薇;樊世锋;闫凯旋
河北医科大学第三医院口腔内科修复科,石家庄 050000河北医科大学第三医院口腔内科修复科,石家庄 050000河北医科大学第三医院口腔内科修复科,石家庄 050000河北医科大学第三医院口腔内科修复科,石家庄 050000
牙周炎2型糖尿病甘氨酸龈下喷砂牙龈下刮治术牙菌斑指数龈沟液炎症因子
periodontitistype 2 diabetes mellitusglycine subgingival air polishingsubgingival scalingplaque indexgingival crevicular fluidinflammatory factors
《转化医学杂志》 2026 (3)
408-413,6
河北省2023年度医学科学研究项目(20230740)
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