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数智化时代胃癌诊治新进展与未来研究方向OA

New progress and future research directions in the diagnosis and treatment of gastric cancer in the era of digital intelligence

中文摘要英文摘要

近年来,随着高质量循证医学证据的不断积累,以规范化手术为核心,联合围术期化疗及免疫治疗的综合治疗模式逐步确立,显著提升了胃癌整体诊疗水平.然而,传统以"标准化"为导向的诊疗路径在应对胃癌高度异质性的生物学特征及日益复杂的治疗决策时,逐渐显现出局限性.随着人工智能、机器人辅助手术、多模态影像融合及数据科学等技术的快速发展,胃癌诊治正在由经验驱动和流程标准化,迈向以数据整合和智能决策为特征的"数智化"新阶段.现有研究表明,人工智能辅助影像筛查与分期评估、近红外荧光显像技术、基于数据驱动的质量控制体系,以及对肿瘤免疫微环境的系统性解析,正在从手术技术、个体化治疗、质量管理和基础研究等多个层面重塑胃癌诊治与研究范式.

In recent years,with the continuous accumulation of high-quality evidence,a comprehensive treatment paradigm centered on standardized surgery and combined with perioperative chemotherapy and immunotherapy has been gradually established,leading to substantial improvements in overall outcomes for gastric cancer management.However,traditional treatment pathways oriented toward"standardization"have increasingly revealed limitations in addressing the pronounced biological heterogeneity of gastric cancer and the growing complexity of therapeutic decision-making.With the rapid development of artificial intelligence,robotic-assisted surgery,multimodal imaging integration,and data science,the diagnosis and treatment of gastric cancer are undergoing a paradigm shift-from experience-driven practice and process standardization toward a new stage of"digital and intelligent"medicine characterized by data integration and intelligent decision-making.Emerging evidence indicates that artificial intelligence-assisted imaging screening and staging,novel near-infrared fluorescence imaging technologies,data-driven quality control systems,and systematic analyses of the tumor immune microenvironment are collectively reshaping the paradigms of gastric cancer management and research across multiple dimensions,including surgical techniques,individualized treatment strategies,quality management,and basic research.By integrating representative advances from both domestic and international studies,together with the authors' team's practical experience in international collaborations.

季加孚;李浙民;李子禹

北京大学肿瘤医院暨北京市肿瘤防治研究所胃肠肿瘤中心消化系肿瘤整合防治全国重点实验室,北京 100142北京大学肿瘤医院暨北京市肿瘤防治研究所胃肠肿瘤中心恶性肿瘤发病机制及转化研究教育部重点实验室,北京 100142北京大学肿瘤医院暨北京市肿瘤防治研究所胃肠肿瘤中心恶性肿瘤发病机制及转化研究教育部重点实验室,北京 100142

医药卫生

胃癌数智化个体化治疗人工智能质量控制

gastric cancerdigital intelligencetailored therapyartificial intelligencequality control

《中国实用外科杂志》 2026 (1)

15-18,4

National Natural Science Foundation of China(Major Program,No.92259302) 国家自然科学基金重大研究项目(No.92259302)

10.19538/j.cjps.issn1005-2208.2026.01.04

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