滋肾育胎丸辅助环孢素A对复发性流产患者性激素、子宫超声血流及Th17/Treg的影响OA
Effect of Zishen Yutai Pill as an Adjunct to Cyclosporine A on Sex Hormones,Uterine Ultrasound Blood Flow and Th17/Treg in Patients with Recurrent Spontaneous Abortion
目的:探究滋肾育胎丸辅助环孢素A对复发性流产(RSA)患者性激素、子宫超声血流及辅助性T细胞17(Th17)/调节性T细胞(Treg)的影响.方法:前瞻性选取 2021年 7 月～2024年1月本院收治的120 例RSA患者,采用随机数字表法分为对照组和联合组,每组60例.对照组给予环孢素软胶囊治疗,观察组在对照组基础上给予滋肾育胎丸治疗,确认怀孕后持续用药至孕12 周.比较两组中医证候积分、性激素[雌二醇(E2)、孕酮(P)、人绒毛膜促性腺激素(β-hCG)]、子宫超声血流[血管化血流指数(VFI)、血流指数(FI)、血管指数(VI)]、Th17/Treg、妊娠结局及不良反应发生情况.结果:治疗后,联合组腰腹疼痛、阴道暗红出血、体倦乏力、畏寒肢冷、中医证候积分、Th17及Th17/Treg均低于对照组(P＜0.05);E2、P、β-hCG、VFI、FI、VI及Treg均高于对照组(P＜0.05).联合组妊娠成功率(85.71%)高于对照组(60.34%,P=0.015).两组不良反应总发生率比较无统计学差异(P＞0.05).结论:滋肾育胎丸辅助环孢素A治疗RSA效果显著,能有效调控性激素,改善子宫超声血流,减轻中医证候,提高妊娠成功率,其机制可能与逆转Th17/Treg失衡有关.
Objective:To investigate the effects of Zishen Yutai Pill as an adjunct to cyclosporine A on sex hormones,uterine ultrasound blood flow,and helper T cell 17(Th17)/regulatory T cell(Treg)in patients with recurrent spontaneous abortion(RSA).Methods:A total of 120 RSA patients admitted to our hospital from July 2021 to January 2024 were prospectively selected and divided into the control group and the combined group by random number table method,with 60 patients in each group.The control group was treated with cyclosporine soft capsules,while the combined group was administered Zishen Yutai Pill on the basis of the control group's treatment.Medication was continued until the 12th week of gestation after pregnancy confirmation.TCM syndrome scores,sex hormones[estradiol(E2),progesterone(P),human chorionic gonadotropin(β-hCG)],uterine ultrasound blood flow indexes[vascularization flow index(VFI),flow index(FI),vascular index(VI)],Th17/Treg ratio,pregnancy outcomes,and incidence of adverse reactions were compared between the two groups.Results:After treatment,the scores of lumbago and abdominal pain,vaginal dark red bleeding,physical fatigue and weakness,aversion to cold and cold limbs,total TCM syndrome score,the level of Th17,and the Th17/Treg ratio in the combined group were all lower than those in the control group(P<0.05);the levels of E2,P,β-hCG,VFI,FI,VI and Treg in the combined group were all higher than those in the control group(P<0.05).The pregnancy success rate of the combined group(85.71%)was higher than that of the control group(60.34%,P=0.015).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Zishen Yutai Pill as an adjunct to cyclosporine A exerts a significant effect in the treatment of RSA,which can effectively regulate sex hormones,improve uterine ultrasound blood flow,alleviate TCM syndromes,and increase the pregnancy success rate.Its mechanism may be related to reversing the Th17/Treg imbalance.
武明莉;杨小风;刘芳;娄欢;党丽英
郑州大学附属郑州中心医院,郑州 450007郑州大学附属郑州中心医院,郑州 450007郑州大学附属郑州中心医院,郑州 450007郑州大学附属郑州中心医院,郑州 450007郑州大学附属郑州中心医院,郑州 450007
医药卫生
复发性流产滋肾育胎丸环孢素A性激素子宫超声血流辅助性T细胞17/调节性T细胞失衡
recurrent spontaneous abortionZishen Yutai Pillcyclosporine Asex hormonesuterine ultrasound blood flowTh17/Treg imbalance
《中国合理用药探索》 2026 (2)
71-76,6
2023年度郑州市科技惠民计划项目(2023KJHM0015)
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