基于隐结构模型和关联规则分析梅尼埃病方药规律OA

Objective To explore the prescription law of TCM treatment for Ménière's disease;To provide clinical references.Methods Relevant literature about TCM treatment for Ménière's disease was retrieved from CNKI,Wanfang Data,VIP,SinoMed,PubMed,Web of Science,Cochrane Library,Embase from the establishment of the databases to March 4,2025.Data analysis was conducted on frequency,properties and tastes,meridian tropism and efficacy of Chinese materia medica using Excel 2019.Lantern 5.0 and RStudio were used to perform latent structure modeling,clustering analysis,and association rule analysis on high-frequency Chinese materia medica with a usage frequency of≥3%.Results A total of 397 articles were included,including 441 prescriptions,which involving 222 herbs,with a total frequency of 4 848 times.High-frequency Chinese materia medica included Atractylodis Macrocephalae Rhizoma,Poria,Alismatis Rhizoma and Gastrodiae Rhizoma.The main properties were warm,neutral and cold;the main tastes were sweet,pungent and bitter,mainly entering the spleen,lung and stomach meridians.Key efficacy included tonifying deficiency,promoting diuresis and draining dampness,and calming the liver and extinguishing wind.Latent structure analysis revealed 21 latent variables,42 latent classes,and 7 cluster models,summarizing 25 core formulas.The main syndrome patterns identified were phlegm-dampness obstruction,kidney essence deficiency,liver yang hyperactivity,and qi-blood deficiency.Association rule analysis yielded 47 strong rules;the highest support was Poria → Atractylodis Macrocephalae Rhizoma,and the highest confidence was Atractylodis Macrocephalae Rhizoma+Citri Reticulatae Pericarpium+Glycyrrhizae Radix et Rhizoma → Poria.Conclusion Ménière's disease is characterized by liver-kidney deficiency,qi-blood deficiency,and marrow sea insufficiency in root,with manifestations of wind,fire,phlegm and stasis disturbing the orifices.Treatment should focus on tonifying deficiency and draining excess,harmonizing yin and yang,combined with method of resolving phlegm,dispelling dampness,regulating qi,unblocking stagnation,nourishing the liver and kidney,and calming the liver and subduing yang.