不同输注疗程的人血白蛋白对新生儿坏死性小肠结肠炎术后住院预后的影响150例回顾性队列研究OA

Background Empirical albumin supplementation is routinely given to neonates with necrotizing enterocolitis after surgery.It is not clear whether the amount of albumin supplementation is beneficial after surgery.Objective To analyze on whether human blood albumin with different infusion courses can improve the recent prognosis of necrotizing enterocolitis in neonatal.Design Retrospective cohort study.Methods A total of 181 children with neonatal necrotizing enterocolitis who underwent surgical treatment in the Children's Hospital Affiliated to Chongqing Medical University from June 2017 to August 2023 were selected as the research subjects.Thirteen patients who died after surgery and 18 patients who were discharged for non-medical reasons within 1 week after surgery were excluded.Finally,150 children were included and divided into a short-course group(≤5 days)and a long-course group(>5 days)according to the albumin treatment time.The clinical data of the two groups were compared and analyzed.Main Outcome Measures Postoperative incision/anastomosis complications,secondary surgery rate,and hospital stay.Results There were 96 cases and 54 cases in the short-term and long-term treatment groups,respectively,and there was no significant difference in gender,gestational week and birth weight between the two groups(P>0.05).There were no significant differences between the two groups during the perinatal period,clinical manifestations,preoperative general conditions,preoperative laboratory results,and surgical conditions(P>0.05).The short-term treatment group had gestational diabetes,postoperative hemoglobin amount,postoperative coagulation dysfunction ratio,postoperative invasive ventilator use time,postoperative gastrointestinal decompression time,postoperative milk opening time,central venous catheterization time,postoperative 70%/full enteral nutrition time were significantly lower than those in the long-term treatment group(P<0.05),but the postoperative platelet count was significantly higher than that in the long-term treatment group(P<0.05).There was no significant difference in postoperative incision/anaxotomy complications,secondary surgery rate,hospital stay and discharge weight between the two groups(P>0.05).Conclusion Prolonged albumin infusion will not benefit the main near-term outcome indicators of children with necrotizing enterocolitis(postoperative incision/anastomosis complications,secondary surgery rate,and hospital stay).