基于数据挖掘分析周尚昆治疗干眼的用药规律OA

OBJECTIVE To analyze the medication patterns of ZHOU Shangkun in treating dry eye based on data mining.METHODS Medical records of dry eye patients treated at ZHOU Shangkun´s specialized dry eye clinic at Wangjing Hospital,China Academy of Chinese Medical Sciences,from January 2018 to December 2023 were collected.Records were screened according to inclusion and exclusion criteria,and the information was structured and standardized.The data were imported into the Traditional Chinese Medicine(TCM)Inheritance Computing Platform V3.0 for processing and analysis.Python 3.9.7 was used for closed frequent itemset mining,and the results were refined using the minimum coverage frequent itemset compression method to output core medicine combinations.RESULTS(1)General information:A total of 2,734 dry eye medical records were collected,and 1,928 were included after screening.The manual review accuracy for symptom extraction was 91.3%,and the consistency rate for medication coding was 95.6%.(2)Frequency of Chinese medicine and other treatments:There were 1,206 medicine prescriptions involving 242 medicines.The top three most frequently used medicines were Chrysanthemi flos(630 times,52.23%),Tribuli fructus(606 times,50.25%),and Menthae haplocalycis herba(588 times,48.76%).There were 722 prescriptions for other treatments involving 17 modalities.The top three most frequently used treatments were conjunctival sac irrigation(657 times,52.23%),pulsed therapy(191 times,26.45%),and TCM directional medicine penetration therapy(189 times,26.18%).(3)Analysis of medication patterns:A total of 256 closed frequent itemsets were obtained using the minimum coverage method,which completely covered all prescription patterns.After further screening,16 representative closed frequent itemsets with high frequency,non-single medicine composition,and high differentiation ratios were identified.The top two medicine combinations were:① Rehmanniae radix,Chuanxiong rhizoma,Angelicae sinensis radix,Angelicae dahuricae radix,Saposhnikoviae radix,Tribuli fructus,Paeoniae radix rubra,Moutan cortex,Menthae haplocalycis herba;② Polygonati odorati rhizoma,Polygonati rhizoma,Rehmanniae radix praeparata,Salvia miltiorrhiza bunge,Angelicae sinensis radix,Menthae haplocalycis herba.CONCLUSIONS ZHOU Shangkun´s treatment of dry eye is primarily based on the principles of"nourishing Yin and blood,unblocking collaterals,and moistening the eyes".Medicine prescriptions are dominated by Yin-nourishing medicines combined with collateral-unblocking agents.Western Medical and appropriate TCM techniques are also applied.This study provides an objective reference for the clinical treatment of dry eye.