基于肠-肝-脑轴理论论治儿童抽动障碍的探讨OA

Tic disorder is a chronic neuropsychiatric disorder predominantly affecting children and adolescents.In traditional Chinese medicine,its pathogenesis is primarily located in the liver,spleen,and brain,with the core mechanism being"disharmony of brain marrow and spiritual mechanism,and dysfunction of liver-spleen conveyance and drainage."Based on the"gut-liver-brain axis"theory,"dysfunction of liver-spleen conveyance and drainage"corresponds to intestinal microbiota dysbiosis,intestinal barrier damage,and hepatic metabolic dysfunction in modern medical concepts,which subsequently influence neuroimmune responses in the brain,leading to"disharmony of brain marrow and spiritual mechanism"Modulating brain function through intervening the intestinal microbiota,reducing hepatic burden,and downregulating inflammatory factors offers new therapeutic targets for the treatment of tic disorder.Traditional Chinese medicine approaches,including herbal formulas and acupuncture,can ameliorate tic symptoms by regulating the intestinal microecology and mitigating neuroinflammation.The"gut-liver-brain axis"theory provides a novel perspective and direction for the clinical management of tic disorder.