润肠丸联合西药治疗产后便秘临床研究OA
Clinical Study of Runchang Wan Combined with Western Medicine in Treating Post-partum Constipation
目的:观察润肠丸联合西药治疗产后便秘的疗效.方法:选取2023年7月—2024年7月舟山市普陀区人民医院就诊的70例产后便秘患者,按随机数字表法分为试验组及对照组各35例.对照组接受西药常规治疗,试验组在对照组基础上联合润肠丸口服治疗.2组均连续治疗4周.比较2组临床疗效及不良反应发生情况,比较2组治疗前后中医证候积分、便秘严重程度[便秘严重程度量表(PAC-SYM)评分]、生活质量[便秘生活质量量表(PAC-QOL)评分]、胃肠激素[P物质(SP)、血管活性肠肽(VIP)]水平的变化.结果:治疗后,试验组临床疗效总有效率为91.43%(32/35),对照组为74.29%(26/35),2组临床疗效比较,差异有统计学意义(P＜0.05).治疗后,2组中医证候积分均较治疗前下降(P＜0.05),试验组中医证候积分低于对照组(P＜0.05).治疗后,2组PAC-SYM评分均较治疗前下降(P＜0.05),试验组PAC-SYM评分低于对照组(P＜0.05).治疗后,2组PAC-QOL评分均较治疗前下降(P＜0.05),试验组PAC-QOL评分低于对照组(P＜0.05).治疗后,2组SP水平均较治疗前提升(P＜0.05),VIP水平均较治疗前下降(P＜0.05);试验组SP水平高于对照组(P＜0.05),VIP水平低于对照组(P＜0.05).结论:润肠丸联合西药治疗产后便秘疗效较好,能改善排便,提高生活质量.
Objective:To observe the efficacy of Runchang Wan combined with western medicine in treating postpartum constipation.Methods:Seventy postpartum constipation patients treated at Zhoushan Putuo District People's Hospital from July 2023 to July 2024 were selected and randomly divided into a trial group(n=35,treated with Runchang Wan combined with western medicine)and a control group(n=35,treated with western medicine alone).Both groups were treated continuously for four weeks.Clinical efficacy and incidence of adverse reactions were compared between the two groups.Changes in traditional Chinese medicine syndrome scores,constipation severity[Patient Assessment of Constipation Symptoms(PAC-SYM)scores],quality of life[Patient Assessment of Constipation Quality of Life(PAC-QOL)scores],and gastrointestinal hormone levels[substance P(SP),vasoactive intestinal peptide(VIP)]were compared between the two groups before and after treatment.Results:After treatment,the total effective rate was 91.43%(32/35)in the trial group and 74.29%(26/35)in the control group,the difference being significant(P＜0.05).After treatment,the traditional Chinese medicine syndrome scores of the two groups were decreased compared with those before treatment(P＜0.05),and the traditional Chinese medicine syndrome scores of the trial group were lower than those of the control group(P＜0.05).After treatment,the PAC-SYM scores of the two groups were decreased compared with those before treatment(P＜0.05),and the PAC-SYM scores of the trial group were lower than those of the control group(P＜0.05).After treatment,the PAC-QOL scores of the two groups were decreased compared with those before treatment(P＜0.05),and the PAC-QOL scores of the trial group were lower than those of the control group(P＜0.05).After treatment,SP levels of the two groups were increased compared with those before treatment(P＜0.05),and VIP levels were decreased compared with those before treatment(P＜0.05);the SP level of the trial group was higher than that of the control group(P＜0.05),and the VIP level of the trial group was lower than that of the control group(P＜0.05).Conclusion:Runchang Wan combined with western medicine demonstrates good efficacy in treating postpartum constipation,improving bowel movements,and enhancing quality of life.
王宁宁;鲍敏莹;范彦;王海娜
舟山市普陀区人民医院,浙江 舟山 316100舟山市普陀区人民医院,浙江 舟山 316100舟山市普陀区人民医院,浙江 舟山 316100舟山市普陀区人民医院,浙江 舟山 316100
医药卫生
产后便秘润肠丸中医证候积分生活质量
Postpartum constipationRunchang WanTraditional Chinese medicine syndrome scoresQuality of life
《新中医》 2026 (5)
44-48,5
2020年浙江省医药卫生科技项目(2020KY340)
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