儿童中重度特应性皮炎系统治疗进展OA

Atopic dermatitis(AD)is a chronic,recurrent,pruritic,type 2 inflammatory skin disease that commonly affects children.AD is primarily characterized by eczematous skin lesions,intense itching and elevated serum IgE levels,and is often associated with food allergy,asthma and allergic rhinitis.Pediatric cases of mild AD are often controlled by topical corticosteroids and/or calcineurin inhibitors.However,pediatric patients with moderate-to-severe AD usually require systemic therapies.Currently,first-line systemic treatments for moderate-to-severe AD include biologics,cyclosporine and corticosteroids,while second-line treatment mainly consists of JAK inhibitors and other traditional immunosuppressants.This article focuses on the latest advances in the systemic pharmacological therapies.