酸敏感性离子通道1a在毒品滥用中的研究进展OA
Research advances in role of acid-sensing ion channel 1a in drug abuse
酸敏感性离子通道 1a(ASIC1a)作为质子门控的阳离子通道,在中枢神经系统中广泛表达,可通过调节钙、钠离子内流、神经突触可塑性及奖赏效应等参与多种生理与病理过程.研究发现,ASIC1a在毒品滥用中发挥了重要作用,其通过调控神经元兴奋性、突触可塑性和奖赏环路等成为毒品成瘾机制研究和潜在治疗靶点的重要分子.本文综述了ASIC1a的分子特性、神经调控机制和对毒品滥用的调控作用,旨在为揭示毒品成瘾机制提供新的靶点,为探索毒品成瘾戒断治疗提供新的策略.
Acid-sensing ion channel 1a(ASIC1a)is a proton-gated cation channel that is widely expressed in the central nervous system,and is involved in various physiological and pathological processes by regulating calcium and sodium influx,synaptic plasticity,and reward effects.Recent studies have demonstrated that ASIC1a plays a pivotal role in drug abuse,by modulating neuronal excitability,synaptic plasticity,and reward circuitry.ASIC1a has thus emerged as a key molecule in the mechanisms of drug addiction and as a potential therapeutic target.This review systematically summarizes the molecular characteristics of ASIC1a,its neuroregulatory mechanisms,and its regulatory role in drug abuse,aiming to provide novel targets for elucidating the mechanisms of drug addiction and for the development of new strategies for addiction withdrawal therapy.
普珊;许睿珂;李韵兰;李利华;杨根梦;洪仕君
国家卫健委毒品依赖和戒治重点实验室/昆明医科大学法医学院,昆明 650500国家卫健委毒品依赖和戒治重点实验室/昆明医科大学法医学院,昆明 650500国家卫健委毒品依赖和戒治重点实验室/昆明医科大学法医学院,昆明 650500国家卫健委毒品依赖和戒治重点实验室/昆明医科大学法医学院,昆明 650500国家卫健委毒品依赖和戒治重点实验室/昆明医科大学法医学院,昆明 650500国家卫健委毒品依赖和戒治重点实验室/昆明医科大学法医学院,昆明 650500
医药卫生
酸敏感性离子通道1a毒品成瘾突触可塑性钙超载神经炎症线粒体功能障碍
acid-sensing ion channel 1adrug addictionsynaptic plasticitycalcium overloadneuroinflammationmitochondrial dysfunction
《中国比较医学杂志》 2026 (3)
100-108,9
国家自然科学基金项目(82202081,82260336,82371898)云南省科技厅基础研究项目(202301AT070269,202301AU070216)云南省科技厅-昆医联合专项(202301AY070001-234,202301AY070001-026)昆明医科大学法医毒物学一流学科团队(2024XKTDYS10).
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