基因组选择技术在作物育种中的应用与进展OA
Applications and advances of genomic selection in crop breeding
为全面揭示基因组选择(genomic selection,GS)技术在作物遗传育种中的现状和应用潜力,以"基因组选择""作物育种""深度学习""统计模型"为关键词,在Web of Science、中国知网等数据库中检索相关文献共253篇,系统总结基因组选择技术的理论基础、方法演进、模型优化、应用实例等方面的进展和面临的挑战,重点分析采用多组学融合、神经网络等具体方法以提升基因组选择技术辅助育种的预测准确性.结果表明:基因组选择技术已从传统表型选择理论拓展至整合高通量基因组数据的现代育种实践,基因组选择模型亦由早期的以最佳线性无偏预测模型为(BLUP)核心的线性模型统计方法逐步演变为贝叶斯模型(Bayes model)、正则化方法、多性状预测、多环境反应规范模型和机器学习与深度学习模型,特别是在复杂性状预测中展现出显著优势.同时,大豆等重要作物已成为基因组选择辅助育种应用的典型代表,涵盖模型训练、训练群体优化及基因型-环境互作建模等方面.GS的突破有赖于多组学数据整合、环境-基因互作建模、可解释性算法、多模态深度学习框架,以及面向育种实践的大规模训练集构建等.可见,GS正逐步形成支撑新一代智能化育种体系的关键技术支柱,在耕地资源紧张与气候变化背景下,为实现作物遗传增益与可持续育种提供重要的支点.
To comprehensively elucidate the current status and application potential of genomic selection(GS)in crop genetic improvement and breeding,a total of 253 publications from Web of Science and CNKI were retrieved by using"genomic selection","crop breeding","deep learning"and"statistical models"as keywords.This study systematically summarized research progress in theoretical foundations,methodological evolution,model optimization,application cases,and outstanding challenges of GS,and focused on how specific strategies,such as multi-omics integration and neural-network-based approaches,can improve the predictive accuracy of GS-assisted breeding.The results indicate that:GS has expanded from conventional phenotype-based selection theory to modern breeding practices that integrate high-throughput genomic data.Meanwhile,GS models have evolved from early linear statistical approaches centered on best linear unbiased prediction to Bayesian models,regularization methods,multi-trait prediction,genotype-by-environment(G×E)modeling frameworks,and machine-learning and deep-learning models,which have shown marked advantages for predicting complex traits.In addition,major crops such as soybean have become representative systems for applying GS in breeding,encompassing model training,optimizing of training populations,and modeling of G×E interaction.In the future,breakthroughs in GS will depend on multi-omics data integration,robust modeling of environment-genotype interactions,interpretable algorithms,multimodal deep-learning frameworks,and the construction of large-scale training datasets tailored to practical breeding programs.Overall,GS is becoming the key technological pillar of next-generation intelligent breeding systems and providing an important leverage point for achieving genetic gain and sustainable crop improvement under constraints of limited arable land and ongoing climate challenges.
孙连军;王宏畅;方婷;肖国政;侯晶晶;闫军;汪海;管旭东;王作平
中国农业大学农学院,北京 100193中国农业大学农学院,北京 100193||三亚大北农创种基因科技有限公司,海南三亚 572024中国农业大学农学院,北京 100193中国农业大学农学院,北京 100193中国农业大学农学院,北京 100193中国农业大学农学院,北京 100193中国农业大学农学院,北京 100193三亚大北农创种基因科技有限公司,海南三亚 572024三亚大北农创种基因科技有限公司,海南三亚 572024
农业科技
基因组选择BLUP贝叶斯方法机器学习
genomic selectionBLUPBAYESmachine learning
《中国农业大学学报》 2026 (4)
1-12,12
国家自然科学基金(32072089)
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