肠道病毒71感染的免疫逃逸机制研究进展OA

Enterovirus 71(EV71)is a positive-sense single-stranded RNA virus responsible for severe diseases such as hand,foot,and mouth disease and neurological damage in young children.The process of EV71 infection involves intricate interac-tions between the virus and the host immune system.Crucially,EV71 evades immune attack by interfering with multiple host immune signaling pathways,thereby promoting its survival and replication.This article begins with a brief description of the EV71 infection process,initiated by binding to host cell surface receptors.It highlights the pivotal roles played by both its structural and non-structur-al proteins in viral entry and subsequent immune evasion.The review focuses in detail on the mechanisms employed by EV71 to evade host immunity.These mechanisms include:Inhibition of innate immune signaling pathways,evasion of adaptive immune responses,modulation of host cell apoptosis and autophagy and interference with the complement system.A deeper understanding of EV71's infec-tion mechanisms and immune evasion strategies is essential for elucidating the molecular basis of its pathogenesis.Furthermore,this knowledge provides a critical theoretical foundation for developing more effective antiviral therapeutics and vaccines.