儿童重症肺炎支原体肺炎继发感染后闭塞性细支气管炎的危险因素研究OA

Objective To investigate independent risk factors for post-infectious bronchiolitis obliterans(PIBO)in chil-dren with severe Mycoplasma pneumoniae pneumonia(SMPP),so as to provide evidence for early identification of high-risk patients.Methods A total of 230 children with SMPP who were diagnosed and treated at Quanzhou Maternal and Child Health Hospital·Children's Hospital from January 2018 to January 2024 were enrolled.They were divided into case group(n=54)and control group(n=176)based on the occurrence of PIBO.And then,general characteristics,biological,and clinical features were compared between the PIBO case group and control group,and variables identified in univariate analy-sis(P<0.1)were included in a multivariate logistic regression model to identify independent risk factors.Results Univari-ate analysis revealed that multiple clinical severity-related variables,as well as inflammation and coagulation-related indica-tors,were associated with PIBO(P<0.05).In multivariate analysis,the duration from symptom onset to admission(OR=1.084,95%CI:1.035-1.135,P=0.001)and D-dimer(OR=1.446,95%CI:1.087-1.925,P=0.011)were in-dependent risk factors.Conclusion Delayed presentation and elevated D-dimer levels are independent risk factors for sec-ondary PIBO after SMPP,which provides biologically plausible rationale for early clinical identification and intervention.