肝主生发的传承创新OA
Inheritance and innovation of"the liver governing growth and development"theory in TCM
肝主生发的理论认识虽早见于《内经》,但后世对其理论价值重视不够,概念不明确,临床实践不充分、不规范,基础研究不全面、不深入,妨碍了中医药学的发展.该文传承《内经》有关肝主生发的核心思想,明确肝主生发的内涵与外延,厘清肝主生发与肝主升发、肝主疏泄的区别与联系.概括总结了肝藏具有主管以肝脏为中心的相关脏腑组织的发生发育和再生修复结构功能体系的作用及其机制,中医药具有通过调控发生发育和再生修复失衡防治肝脏为中心相关脏腑组织病证的作用及其机制的定义内涵与外延.重点介绍了肝主生发指导中医药调控肝再生修复的创新研究、中医药调控免疫细胞再生修复防治艾滋病患者免疫重建不全的创新研究、中医药对生长发育的创新研究、中医药对肝癌肿瘤发生发展与复发转移的创新研究、中医药影响肝再生微环境防治肝癌发生发展与复发转移的创新研究、中医药改善肿瘤患者恶病质的创新研究.明确现存的问题与进一步研究方向,推动肝主生发理论的继承创新及中医药学的发展.
Although the theoretical understanding of"the liver governing growth and development"theory was first documented in the Yellow Emperor's Canon of Medicine(黄帝内经),its theoretical value has been insufficiently emphasized in later generations,with unclear concepts,inadequate and non-standardized clinical practices,as well as incomplete and superficial fundamental research,which has hindered the development of traditional Chinese medicine(TCM).This paper inherits the core ideas related to"the liver gov-erning growth and development"from the Yellow Emperor's Canon of Medicine,clarifies its connotation and denotation,and distin-guishes the differences and connections between"the liver governing growth and development","the liver governing ascending and dis-persing",and"the liver governing dredging and discharging".It summarizes the role and mechanisms of the liver system in overseeing the structural and functional system for the generation,development,and regenerative repair of liver-centered viscera and tissues,as well as the definition,connotation,and denotation of how TCM prevents and treats liver-centered viscera and tissue disorders by regulat-ing imbalances in growth,development,and regenerative repair.The paper highlights the innovative research on"the liver governing growth and development"guiding TCM in regulating liver regeneration and repair,innovative research on TCM regulating immune cell regeneration and repair to prevent and treat inadequate immune reconstitution in AIDS patients,innovative research on TCM in growth and development,innovative research on TCM regarding the occurrence,development,recurrence,and metastasis of liver cancer,inno-vative research on TCM influencing the liver regeneration microenvironment to prevent and treat the occurrence,development,recur-rence,and metastasis of liver cancer,and innovative research on TCM improving cachexia in cancer patients.It identifies the existing problems and directions for further research,promoting the inheritance and innovation of the theory of"the liver governing generation and development",thereby advancing the development of TCM.
李瀚旻
湖北中医药大学附属湖北省中医院藏象肝病研究所,湖北 武汉 430061||国家中医药管理局中医药科研细胞分子生物学三级实验室,湖北 武汉 430061||国家中医药管理局慢性肝病肝肾论治重点研究室,湖北 武汉 430061||中医肝肾研究及应用湖北省重点实验室,湖北 武汉 430061||湖北时珍实验室,湖北 武汉 430061
医药卫生
肝主生发发生发育再生修复肿瘤防治
The liver governing growth and developmentGrowth and developmentRegeneration and repairTumor prevention and treatment
《时珍国医国药》 2026 (3)
401-409,9
国家自然科学基金(81973669,81774280,81703912,81603484,81573815,81274147)国家中医临床研究基地(湖北)重点病种研究项目(JDZX2015172)李瀚旻湖北中医名师传承工作室资助项目[鄂卫生计生办通(2018)32号]湖北省自然科学基金(2022CFD134)广西壮族自治区中医药管理局重症肝病多学科交叉创新团队项目(GZKJ2306)
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