aEEG评分联合血清CK-BB、VILIP-1水平对早产儿脑损伤的预测价值OA

Objective:To evaluate the predictive value of amplitude-integrated electroencephalography(aEEG)score combined with serum Creatine kinase-BB(CK-BB)and visinin-like protein 1(VILIP-1)for brain injury in pre-mature infants.Methods:90 premature infants with brain injury were used as brain injury group,and 55 premature in-fants without brain injury were used as control group.The brain function monitor was used to monitor and obtain aEEG parameters of premature infants.Enzyme linked immunosorbent assay was used to detect serum CK-BB and VILIP-1 in premature infants.Logistic regression was used to analyze the influencing factors of brain injury in prema-ture infants.ROC curve was used to evaluate the value of aEEG score and serum CK-BB,VILIP-1 in predicting brain injury in premature infants.Results:The proportions of premature infants whose mothers complicated with gestation-al diabetes and placental abnormalities in brain injury group were higher than those in the control group(all P<0.05).Compared with control group,the aEEG continuity score,sleep-wake cycle score,lower boundary amplitude score,and total score of premature infants in the brain injury group were significantly reduced,while serum CK-BB and VILIP-1 levels were significantly increased(all P<0.05).Premature infants with mothers complicated with gesta-tional diabetes and elevated serum CK-BB and VILIP-1 were risk factors for brain injury,and the increase in parame-ter scores of aEEG were the protective factors(all P<0.05).The AUC of the combined prediction of serum CK-BB,VILIP-1,and aEEG score for brain injury in premature infants was significantly higher than that of each individual detection(all P<0.05).Conclusion:The aEEG score and serum CK-BB,VILIP-1 have high clinical application value in predicting brain injury in premature infants,and the predictive value of the three combined is higher.