西安地区ACR TI-RADS 4类及以上甲状腺结节超声检出现状及其与代谢指标相关性研究OA

Objective:To explore the current situation of the ultrasonic detection of thyroid nodules of ACR TI-RADS category 4 and above(high-risk thyroid nodules)among the population undergoing health examinations in Xi'an region,as well as the relationship between these nodules and metabolic indicators.Methods:A retrospective cross-sec-tional study was conducted on 9402 subjects.The detection rate of high-risk thyroid nodules was statistically analyzed with age as the stratification variable and gender as the grouping variable.Potential risk factors were analyzed using univariate analysis,followed by multivariate binary Logistic regression to identify independent predictors of high-risk thyroid nodules.Results:The overall proportion of high-risk thyroid nodules was 8.81%(828/9402),it was 7.42%(319/4297)in males and 9.97%(509/5105)in females.Among males,the proportion of high-risk thyroid nodules was the highest(9.05%)in the age group of 40 to 50 years old,but there was no linear relationship between the proportion of high-risk thyroid nodules and age(P>0.05).For females,the proportion of high-risk thyroid nod-ules increased with age(P<0.001).The proportion of high-risk thyroid nodules was significantly higher in females than that in males in the age group of 50 to 70 years old(P<0.001),while there was no such difference in other age groups(all P>0.05).Statistically significant disparities existed between the low-risk thyroid nodule group and the high-risk thyroid nodule group in terms of age,BMI,TC,TG,TyG index,non-HDL-C,T3,LDL-C,TgAb,TMAb,as well as the proportion of hypertension and central obesity(all P<0.05).Findings from multivariate binary Logistic regression analyses indicated that female sex(OR=1.640),central obesity(OR=1.244),hypertension(OR=1.251),elevated TyG index(OR=1.223),elevated T3 level(OR=1.336)and elevated TgAb level(OR=1.005)were independent risk factors for high-risk thyroid nodules(all P<0.05).Conclusion:In Xi'an region,among males,the proportion of high-risk thyroid nodules was the highest in the age group of 40 to 50 years old;for females,the proportion of high-risk thyroid nodules increased with age.Individuals who are female,have central obesity,suffer from hypertension and have elevated levels of TyG index,T3 and TgAb have an increased risk of high-risk thyroid nodules.Therefore,it is essential to strengthen the follow-up and management of thyroid nodules for these groups.