血府逐瘀汤治疗肺癌的研究进展:从临床应用到机制探索OA
Research progress on Xuefu Zhuyu Decoction in treatment of lung cancer:from clinical application to mechanism exploration
血府逐瘀汤源于清代王清任所著《医林改错》,为中医活血化瘀经典名方.近年来,该方在肿瘤治疗领域展现出潜在价值,临床研究提示其联合化学疗法可增强抗肿瘤效果.通过系统综述血府逐瘀汤在肺癌治疗中的作用,重点探讨其有效成分在抑制肿瘤血管生成、阻断转移进程、调控细胞衰老及重塑肿瘤免疫微环境等方面的药理作用与分子机制,以阐释该方抗肺癌的现代科学内涵.
Xuefu Zhuyu Decoction,recorded in Yilin Gaicuo(Corrections of Errors in Medical Classics)written by Wang Qingren in the Qing Dynasty,is a classic famous formula for promoting blood circulation and resolving stasis in traditional Chinese medicine.In recent years,this prescription has shown potential value for oncological treatment.Clinical studies have suggested that its combination with chemotherapy can enhance the anti-tumor effect.By systematically reviewing the role of Xuefu Zhuyu Decoction in the treatment of lung cancer,this paper focuses on exploring the pharmacological effects and molecular mechanisms of its active components in inhibiting tumor angiogenesis,blocking metastasis process,regulating cellular senescence,and remodeling the tumor immune microenvironment.The aim is to elaborate the modern scientific connotation of the anti-lung cancer effects of Xuefu Zhuyu Decoction.
王婷;吕玉宝;王轩;杨伊;苏师予;曹玉雪;黄达宇
复旦大学附属华山医院(上海 200040)||上海市嘉定区南翔医院(上海 201802)复旦大学附属华山医院(上海 200040)复旦大学附属华山医院(上海 200040)上海市嘉定区南翔医院(上海 201802)上海市嘉定区南翔医院(上海 201802)复旦大学附属华山医院(上海 200040)复旦大学附属华山医院(上海 200040)
血府逐瘀汤肺癌有效成分血瘀证抗肿瘤机制经典名方
Xuefu Zhuyu Decoctionlung canceractive componentsblood stasis syndromeanti-tumor mechanismclassic famous formula
《上海中医药杂志》 2026 (3)
19-27,9
上海市嘉定区科委自然科学基金项目(JDKW-2024-0019)上海市嘉定区卫健委卫生健康系统特色专病项目(ZB202404)、科研课题项目(2024-KY-ZD-04,2024-QN-ZYY-04)上海市嘉定区南翔医院"科技计划"科研课题(202415B、202412A)
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