从脾论治轻度认知功能损害的理论探讨与针灸干预策略OA

Mild cognitive impairment(MCI)is an unstable transitional state between cognitive decline associated with normal brain aging and Alzheimer's disease.In traditional Chinese medicine(TCM),MCI is classified under conditions such as"amnesia",and its occurrence is considered to be associated with spleen deficiency.The spleen is regarded as the source of qi and blood transformation,and its function of ascending clear yang is essential for maintaining vitality,providing a continuous postnatal material basis for the storage of"intent and intellect"attributed to the spleen.With aging,spleen deficiency may result in impaired transformation and transportation,insufficient generation of qi and blood,deficiency of nutritive blood,and weakened ascending of clear yang.Consequently,clear yang fails to ascend,the brain orifices are deprived of nourishment,turbid yin is generated internally and ascends to disturb the clear orifices,ultimately leading to dysfunction of mental activities.This pathophysiological interpretation offers an integrated perspective on the multifactorial mechanisms of MCI identified by modern medicine,including lipid metabolism disorders,increased oxidative stress,neuroinflammatory responses,and gut microbiota dysbiosis.As a non-pharmacological therapy that regulates visceral qi dynamics,acupuncture and moxibustion may act on multiple pathological processes of MCI by strengthening the spleen and promoting the ascending of clear yang,thereby improving cognitive function.From the TCM theoretical perspective of treating MCI through the spleen,acupuncture and moxibustion intervention strategies are proposed to provide new insights and clinical references for the comprehensive management of MCI.