精神疾病及失眠与肠易激综合征间的双向双样本孟德尔随机化因果关系研究OA

Objective:To analyze the causal relationships between mental disorders,insomnia,and irritable bowel syndrome(IBS)using a bidirectional two-sample Mendelian randomization(MR)approach.Methods:The primary analysis was conducted using the random-effects inverse variance weighted(IVW)method on genome-wide association study summary data.Heterogeneity was assessed using Cochran's Q statistic.The horizontal pleiotropy was tested using the intercept from MR-Egger regression.Results:Forward MR analysis revealed that major depressive disorder,schizophrenia,and insomnia were positively associated with the increased risk of IBS(all P<0.05).Reverse MR analysis indicated that IBS was positively associated with the increased risk of major depressive disorder and insomnia(all P<0.05).Cochran's Q test in the forward MR analysis showed heterogeneity in the causal estimates for the genetic instruments of schizophrenia,insomnia,and bipolar disorder,while no heterogeneity was observed for other outcomes.MR-Egger regression indicated no significant horizontal pleiotropy for any of the results(P>0.05).Conclusion:Major depressive disorder,schizophrenia,and insomnia have causal associations with IBS.