外周血T淋巴细胞亚群联合β-HCG对孕早期先兆流产患者妊娠结局的预测价值OA
Predictive value of peripheral blood T lymphocyte subsets combined with β-HCG for pregnancy outcome in patients with threatened abortion in early pregnancy
目的 探讨外周血T淋巴细胞亚群联合β-人绒毛膜促性腺激素(β-HCG)对孕早期先兆流产患者妊娠结局的预测价值.方法 选取2022年10月至2024年10月陕西省咸阳市中心医院收治的孕早期先兆流产女性患者168例作为研究对象.根据随访妊娠结局分为流产组与未流产组.比较流产组与未流产组T淋巴细胞亚群(CD3+、CD4+、CD8+)及β-HCG水平.收集2组基线资料.采用多因素Logistic回归分析孕早期先兆流产患者发生流产的影响因素.绘制受试者工作特征曲线(ROC)分析CD4+、CD8+、β-HCG单独及联合检测对孕早期先兆流产患者发生流产的预测价值.结果 流产组56例,未流产组112例.流产组雌二醇、CD8+、β-HCG水平均低于未流产组,CD4+水平高于未流产组,差异均有统计学意义(P<0.05).多因素Lo-gistic回归分析结果显示,CD4+水平升高是孕早期先兆流产患者发生流产的危险因素(P<0.05),β-HCG、CD8+水平升高是孕早期先兆流产患者发生流产的保护因素(P<0.05).ROC曲线分析结果显示,CD4+、CD8+、β-HCG单独检测预测孕早期先兆流产患者发生流产的曲线下面积(AUC)分别为0.717、0.713、0.708,三者联合预测的 AUC为0.918,大于CD4+、CD8+、β-HCG单独预测的 AUC(P<0.05).结论 CD4+、CD8+、β-HCG与孕早期先兆流产密切相关,均为孕早期先兆流产的影响因素,三者联合检测对孕早期先兆流产患者发生流产具有较高的预测价值.
Objective To investigate the predictive value of peripheral blood T lymphocyte subsets com-bined with β-human chorionic gonadotropin(β-HCG)for pregnancy outcome in patients with threatened abor-tion in early pregnancy.Methods A total of 168 female patients with threatened abortion in early pregnancy admitted to Xianyang Central Hospital from October 2022 to October 2024 were selected as the research ob-jects.According to the pregnancy outcome,the patients were divided into abortion group and non-abortion group.The levels of T lymphocyte subsets(CD3+,CD4+,CD8+)and β-HCG were compared between the a-bortion group and the non-abortion group.The baseline data of the two groups were collected.Multivariate Logistic regression was used to analyze the influencing factors of threatened abortion in early pregnancy.Re-ceiver operating characteristic curve(ROC)was drawn to analyze the predictive value of CD4+,CD8+,β-HCG alone and combined detection in patients with threatened abortion in early pregnancy.Results There were 56 cases in the abortion group and 112 cases in the non-abortion group.The levels of estradiol,CD8+and β-HCG in the abortion group were lower than those in the non-abortion group,and the level of CD4+was higher than that in the non-abortion group,and the differences were statistically significant(P<0.05).The results of multivariate Logistic regression analysis showed that the increase of CD4+level was a risk factor for abortion in patients with threatened abortion in early pregnancy(P<0.05),and the increase of β-HCG and CD8+lev-els were protective factors for abortion in patients with threatened abortion in early pregnancy(P<0.05).ROC curve analysis results showed that the area under the curve(AUC)of CD4+,CD8+and β-HCG alone in predicting miscarriage in patients with threatened abortion in early pregnancy was 0.717,0.713 and 0.708 re-spectively,and the AUC of combined prediction of the three was 0.918,which was greater than AUC predicted by CD4+,CD8+and β-HCG alone(P<0.05).Conclusion CD4+,CD8+and β-HCG are closely related to threatened abortion in early pregnancy,and they are all influencing factors of threatened abortion in early pregnancy.The combination of the three has a high predictive value for abortion in patients with threatened a-bortion in early pregnancy.
高冬梅;王飞鹏;赵盼盼;李冰
陕西省咸阳市中心医院妇科,陕西 咸阳 712000陕西省咸阳市中心医院妇科,陕西 咸阳 712000陕西省咸阳市中心医院产科,陕西 咸阳 712000西安医学院第一附属医院妇科,陕西 西安 710077
医药卫生
孕早期先兆流产T淋巴细胞亚群β-人绒毛膜促性腺激素预后预测价值
early pregnancythreatened abortionT lymphocyte subsetsβ-human chorionic gonado-tropinprognosispredictive value
《检验医学与临床》 2026 (5)
628-633,6
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