血清miR-185-5p、Bcl-2水平与颅内动脉粥样硬化性狭窄的关系OA

Objective To investigate the relationship between serum miR-185-5p and B-cell lymphoma/leu-kemia-2(Bcl-2)levels and intracranial atherosclerotic stenosis(ICAS).Methods A total of 210 patients with ICAS admitted to Jingmen People's Hospital from September 2023 to March 2025 were selected as the ICAS group,and 105 healthy people who underwent physical examination in Jingmen People's Hospital during the same period were selected as the control group.The levels of miR-185-5p and Bcl-2 in all subjects were detec-ted.Baseline data of all subjects were collected.Pearson correlation was used to analyze the correlation be-tween serum miR-185-5p levels and Bcl-2 levels in ICAS patients.Multivariate Logistic regression was used to analyze the influencing factors of ICAS.The receiver operating characteristic(ROC)curve was drawn to ana-lyze the diagnostic value of serum miR-185-5p,Bcl-2 alone and combined detection for ICAS.Results Com-pared with the control group,the ICAS group had significantly higher proportions of patients with diabetes,hypertension,and smoking,as well as significantly higher white blood cell count,neutrophil count,low-density lipoprotein cholesterol(LDL-C),and Bcl-2 levels(P<0.05),and a significantly lower level of miR-185-5p(P<0.05).Pearson correlation analysis showed that serum miR-185-5p level was negatively correlated with Bcl-2 level in ICAS patients(r=—0.743,P<0.001).Multivariate Logistic regression analysis showed that diabetes,hypertension,smoking,and increased levels of LDL-C and Bcl-2 were risk factors for ICAS(P<0.05),and increased level of miR-185-5 was a protective factor for ICAS(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of serum miR-185-5p combined with Bcl-2 in the diagnosis of ICAS was 0.898,which was greater than 0.802 of serum miR-185-5p and 0.799 of serum Bcl-2(Z=4.244,4.530,P<0.001).Conclusion Decreased serum miR-185-5p level and increased Bcl-2 level are closely related to ICAS,and the combined detection of serum miR-185-5p and Bcl-2 levels has certain diagnostic value for ICAS.