TyG-BMI与SII对T2DM患者合并冠状动脉病变的诊断价值OA

Objective To investigate the diagnostic value of triglyceride-glucose index(TyG)-body mass index(BMI)and systemic immune-inflammation index(SII)for coronary artery disease in patients with type 2 diabetes mellitus(T2DM).Methods A total of 490 patients with T2DM and coronary artery disease admit-ted to the hospital from January 2022 to November 2024 were selected as the diabetic coronary artery disease group,and the patients were divided into mild group,moderate group and severe group according to Gensini score.In addition,100 patients with T2DM without coronary artery disease admitted to the hospital during the same period were selected as the diabetes group.Baseline data of all subjects were collected.Blood routine in-dexes[white blood cell count,platelet count(PLT),PLT/lymphocyte count ratio(PLR)],biochemical inde-xes[uric acid(UA),fasting plasma glucose,total cholesterol(TC),triglyceride,high density lipoprotein cho-lesterol,low density lipoprotein cholesterol,lipoprotein a(LPa),homocysteine,C reactive protein(CRP),gly-cosylated hemoglobin(HbA1c)]were detected in all subjects.TyG-BMI and SII were calculated.Receiver op-erating characteristic(ROC)curve was drawn to analyze the diagnostic value of TyG-BMI,SII alone and com-bined detection for coronary artery disease in T2DM patients.Results The proportion of patients with smok-ing and hypertension,the levels of UA,TC,LPa,PLT,CRP,HbA1c and PLR in the diabetic coronary artery disease group were higher than those in the diabetic group,and the course of diabetes was longer than that in the diabetic group,and the differences were statistically significant(P<0.05).TyG-BMI and SII in the dia-betic coronary artery disease group were higher than those in the diabetic group,and the differences were sta-tistically significant(P<0.05).There were 120 patients in mild group,183 patients in moderate group,and 187 patients in severe group.TyG-BMI and SII in the severe group were higher than those in the moderate and mild groups,and TyG-BMI and SII in the moderate group were higher than those in the mild group,and the differences were statistically significant(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of TyG-BMI and SII in diagnosing coronary artery disease in T2DM patients was 0.758 and 0.789,re-spectively,and the AUC of TyG-BMI combined with SII in diagnosing coronary artery disease in T2DM pa-tients was 0.950,which was greater than the AUC of TyG-BMI or SII alone(Z=4.260,3.950,P<0.05).Conclusion TyG-BMI and SII have a high diagnostic value for coronary artery disease in patients with T2DM,and both can be used as potential indicators for the diagnosis of coronary artery disease in patients with T2DM.