阿尔茨海默病外周与中枢神经免疫交互机制及干预策略OA

Alzheimer's disease(AD)involves complex pathogenic mechanisms and its pathological process implicates an extensive participation of the systemic immune system.This review discussed the core mecha-nisms of peripheral and central neuroimmune crosstalk in AD progression by highlighting how blood-brain barrier disruption and meningeal lymphatic dysfunction mediated the infiltration of peripheral immune cells into the brain,where they established a pro-inflammatory positive feedback loop with microglia.Furthermore,the regulatory roles of key molecules,including apolipoprotein E4,β2-microglobulin and triggering receptor expressed on myeloid cells 2,in neuroimmune communication were also analyzed.Finally,novel intervention strategies targeting the neuroimmune axis,such as immune checkpoint blockade and regulatory T cell adop-tive transfer,were discussed to provide a theoretical basis for clinical precision treatment in AD.