乳腺导管原位癌的病理诊断与风险评估:从基础研究到临床实践OA

With the widespread implementation of breast cancer screening programs,the detection rate of ductal carcinoma in situ(DCIS)has increased significantly.Although the risk of recurrence among patients with DCIS is het-erogeneous,current clinical management strategies often lack risk stratification and may even lead to overtreatment in some cases.Therefore,identifying distinct patient subgroups with varying risks of recurrence and progression,as well as tailoring appropriate clinical management and surveillance strategies for low-risk DCIS,has emerged as a critical area of interest.This review synthesizes recent advances in clinical practice and research to evaluate risk stratification based on pathological features and morphological indicators,with the aim of improving our understanding of the biologi-cal behavior of DCIS and guiding future directions in its management.