RVO对侧眼的RPCP层毛细血管灌注密度和视网膜神经纤维层厚度的研究OA

Objective To measure the retinal nerve fiber layer(RNFL)thickness and radial peripapillary capil-lary plexus(RPCP)perfusion density(PD)in the fellow eyes of unilateral RVO,explore the correlation between these two parameters in the fellow eyes,explain the phenomenon that unilateral RVO have"unhealthy fellow eyes",and provide a reference for revealing the pathogenesis of RVO.Methods Retrospective case-control study.The fellow eyes of 50 pa-tients with unilateral RVO who were admitted to the Department of Ophthalmology,the Affiliated Hospital of Inner Mongo-lia Medical University from June 1 to December 31,2020 were enrolled in the experimental group,and 50 healthy eyes during the same period were included in the control group.Optical coherence tomography(OCT)and optical coherence to-mography angiography(OCTA)were used to acquire peripapillary RNFL thickness maps and RPCP blood flow maps of all subjects,respectively.Matlab software was employed to calculate the capillary perfusion density.Results There was a sta-tistically significant difference in the average RNFL thickness of the peripapillary temporal region(T region)between the experimental group and the control group(P<0.05).The difference in the average peripapillary capillary perfusion density between the two groups was also statistically significant(P<0.05).The RNFL thickness in the superonasal region(NS re-gion),nasal region(N region)and the entire circumference was significantly positively correlated with peripapillary capil-lary perfusion density(r=0.432,P=0.002;r=0.342,P=0.015;r=0.325,P=0.021).No statistically significant differences were observed in peripapillary capillary perfusion density and corresponding regional RNFL thickness between the central retinal vein occlusion(CRVO)subgroup and the branch retinal vein occlusion(BRVO)subgroup.Conclusions The cap-illary perfusion density of the peripapillary RPCP in the fellow eyes of RVO patients is significantly lower than that in healthy eyes,and the RNFL thickness in the peripapillary T region is significantly thinner than that in normal eyes.In ad-dition,the peripapillary capillary perfusion density of the fellow eyes of RVO patients is significantly positively correlated with the RNFL thickness in the NS region,N region and the entire circumference.There are no differences in peripapillary capillary perfusion density and RNFL thickness between CRVO and BRVO patients.The seemingly normal fellow eyes are not actually"healthy eyes",as their peripapillary retinal structure and microcirculation have already undergone changes.